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Indapamide

Also known as: Indapamide

Thiazide-like Diuretic

Route: Oral

5 interactions on record

Indapamide has 5 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Lithium, Norepinephrine, Other Anticholinergic Agents. Patients taking Indapamide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 5
Major: 1
Moderate: 3

Major (1)

Indapamide + Lithium— Interaction with lithium noted in WARNINGS section; indapamide may affect lithium levels and clearance.

Moderate (3)

Indapamide + Norepinephrine— Indapamide may decrease arterial responsiveness to norepinephrine, though diminution is not sufficient to preclude thera…
Indapamide + Other Anticholinergic Agents— Indapamide may add to or potentiate the action of other antihypertensive drugs, requiring monitoring for enhanced hypote…
Indapamide + Telmisartan, Amlodipine And Indapamide— Monitor serum lithium levels during concomitant use [see Drug Interactions with Indapamide ( 7.3 )] . 7.3 Drug Interacti…

Indapamide + Lithium⚠️Major

Interaction with lithium noted in WARNINGS section; indapamide may affect lithium levels and clearance.

Indapamide + Norepinephrine🟡Moderate

Indapamide may decrease arterial responsiveness to norepinephrine, though diminution is not sufficient to preclude therapeutic effectiveness as a pressor agent.

Indapamide + Other Anticholinergic Agents🟡Moderate

Indapamide may add to or potentiate the action of other antihypertensive drugs, requiring monitoring for enhanced hypotensive effects.

Indapamide + Telmisartan, Amlodipine And Indapamide🟡Moderate

Monitor serum lithium levels during concomitant use [see Drug Interactions with Indapamide ( 7.3 )] . 7.3 Drug Interactions with Indapamide Lithium: In general, diuretics should not be given concomitantly with lithium because they reduce its renal clearance and add a high risk of lithium toxicity. Norepinephrine: Indapamide, like thiazide diuretics, may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use.

Indapamide + Tolterodine Tartrateℹ️Unknown

Diuretics Coadministration of tolterodine immediate release up to 8 mg (4 mg bid) for up to 12 weeks with diuretic agents, such as indapamide, hydrochlorothiazide, triamterene, bendroflumethiazide, chlorothiazide, methylchlorothiazide, or furosemide, did not cause any adverse electrocardiographic (ECG) effects.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.