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Sufentanil Citrate

Also known as: Sufentanil Citrate

Route: Epidural, Intravenous

8 interactions on record⛔ Black Box Warning

Sufentanil Citrate has 8 known drug interactions based on U.S. FDA drug labeling data. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Carbamazepine, Diazepam, Erythromycin. Patients taking Sufentanil Citrate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 8
Major: 8

Major (8)

Sufentanil Citrate + Carbamazepine— CYP3A4 inducer that decreases sufentanil plasma concentration, resulting in decreased efficacy or withdrawal syndrome. D…
Sufentanil Citrate + Diazepam— CNS depressant that may cause cardiovascular depression, hypotension, respiratory depression, profound sedation, coma, a…
Sufentanil Citrate + Erythromycin— CYP3A4 inhibitor that increases sufentanil plasma concentration, resulting in increased or prolonged opioid effects incl…
Sufentanil Citrate + Grapefruit Juice— CYP3A4 inhibitor that increases sufentanil plasma concentration, resulting in increased or prolonged opioid effects incl…
Sufentanil Citrate + Ketoconazole— CYP3A4 inhibitor that increases sufentanil plasma concentration, resulting in increased or prolonged opioid effects incl…
Sufentanil Citrate + Phenytoin— CYP3A4 inducer that decreases sufentanil plasma concentration, resulting in decreased efficacy or withdrawal syndrome. D…
Sufentanil Citrate + Rifampin— CYP3A4 inducer that decreases sufentanil plasma concentration, resulting in decreased efficacy or withdrawal syndrome. D…
Sufentanil Citrate + Ritonavir— CYP3A4 inhibitor that increases sufentanil plasma concentration, resulting in increased or prolonged opioid effects incl…

Sufentanil Citrate + Carbamazepine⚠️Major

CYP3A4 inducer that decreases sufentanil plasma concentration, resulting in decreased efficacy or withdrawal syndrome. Discontinuation may cause increased sufentanil levels and serious respiratory depression.

Sufentanil Citrate + Diazepam⚠️Major

CNS depressant that may cause cardiovascular depression, hypotension, respiratory depression, profound sedation, coma, and death when combined with sufentanil.

Sufentanil Citrate + Erythromycin⚠️Major

CYP3A4 inhibitor that increases sufentanil plasma concentration, resulting in increased or prolonged opioid effects including respiratory depression and sedation.

Sufentanil Citrate + Grapefruit Juice⚠️Major

CYP3A4 inhibitor that increases sufentanil plasma concentration, resulting in increased or prolonged opioid effects including respiratory depression and sedation.

Sufentanil Citrate + Ketoconazole⚠️Major

CYP3A4 inhibitor that increases sufentanil plasma concentration, resulting in increased or prolonged opioid effects including respiratory depression and sedation.

Sufentanil Citrate + Phenytoin⚠️Major

Sufentanil Citrate + Rifampin⚠️Major

Sufentanil Citrate + Ritonavir⚠️Major

CYP3A4 inhibitor that increases sufentanil plasma concentration, resulting in increased or prolonged opioid effects including respiratory depression and sedation.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.