Metaxalone has 30 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 21 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Oxycodone And Acetaminophen, Anakinra, Fentanyl. Patients taking Metaxalone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 30
- Contraindicated
- 1
- Major
- 21
- Moderate
- 5
Contraindicated (1)
- Metaxalone + Oxycodone And Acetaminophen— Muscle relaxant CNS depressant that increases risk of hypotension, respiratory depression, profound sedation, coma, and …
Major (21)
- Metaxalone + Anakinra— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
- Metaxalone + Fentanyl— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
- Metaxalone + Hydromorphone Hydrochloride— Concomitant use may result in serotonin syndrome. Frequently evaluate patient during treatment initiation and dose adjus…
- Metaxalone + Levorphanol Tartrate— Can result in serotonin syndrome and increased respiratory depression. Enhance neuromuscular blocking action.
- Metaxalone + Linezolid— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
- Metaxalone + Mao Inhibitors— Concomitant use may result in serotonin syndrome. Carefully observe patient, particularly during treatment initiation an…
- Metaxalone + Meperidine— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
- Metaxalone + Methadone— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
- Metaxalone + Methylene Blue— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
- Metaxalone + Mirtazapine— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
- Metaxalone + Monoamine Oxidase Inhibitors (Maois)— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
- Metaxalone + Morphine Sulfate— Muscle relaxant that can result in serotonin syndrome when used concomitantly. Requires frequent patient evaluation.
- Metaxalone + Nalbuphine Hydrochloride— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dose adjustm…
- Metaxalone + Oxymorphone Hydrochloride— Serotonergic muscle relaxant that may result in serotonin syndrome when used concomitantly.
- Metaxalone + Remifentanil Hydrochloride— Concomitant use may result in serotonin syndrome.
- Metaxalone + Selective Serotonin Reuptake Inhibitors (Ssri)— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
- Metaxalone + Tapentadol Hydrochloride— Serotonergic activity and CNS depression increase risk of serotonin syndrome and respiratory depression.
- Metaxalone + Tcas— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
- Metaxalone + Tramadol— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
- Metaxalone + Trazodone— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
- Metaxalone + Triptans— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
Moderate (5)
- Metaxalone + Alcohol— Sedative effects of metaxalone and alcohol may be additive. Exercise caution and monitor for respiratory depression and …
- Metaxalone + Butorphanol Tartrate— Concomitant use may result in serotonin syndrome; monitor regularly during initiation and dose adjustment.
- Metaxalone + Cns Depressants— Concomitant use may increase risk of sedation and respiratory depression. Closely monitor for signs of respiratory depre…
- Metaxalone + Nitrazepam— Sedative effects of metaxalone and benzodiazepines may be additive. Exercise caution and monitor for respiratory depress…
- Metaxalone + Pentazocine Hydrochloride And Naloxone Hydrochloride— Muscle relaxant affecting serotonergic system may cause serotonin syndrome; careful observation required.