Articaine has 24 known drug interactions based on U.S. FDA drug labeling data. 17 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Bupivacaine Hydrochloride, Lidocaine, Lidocaine 5%. Patients taking Articaine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 24
- Major
- 17
- Moderate
- 7
Major (17)
- Articaine + Bupivacaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Articaine + Lidocaine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Articaine + Lidocaine 5%— Local anesthetic; concurrent use increases risk of methemoglobinemia and requires consideration of total absorbed amount…
- Articaine + Lidocaine And Prilocaine— Local anesthetic; increased risk of methemoglobinemia when concurrently exposed.
- Articaine + Lidocaine Hydrochloride— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
- Articaine + Lidocaine Hydrochloride And Epinephrine Bitartrate— Local anesthetic associated with increased methemoglobinemia risk when used concurrently.
- Articaine + Lidocaine Hydrochloride And Hydrocortisone Acetate— Increased risk of methemoglobinemia when local anesthetics are concurrently used.
- Articaine + Lidocaine Hydrochloride Monohydrate— Concurrent exposure increases risk of methemoglobinemia in patients administered local anesthetics.
- Articaine + Lidocaine Patch 5%— Increased risk of methemoglobinemia when concurrently exposed; local anesthetics have additive risk when used concomitan…
- Articaine + Lidocaine, Isopropyl Alcohol— Increased risk of methemoglobinemia when used with lidocaine.
- Articaine + Lidocaine, Menthol— Increased risk of methemoglobinemia when lidocaine is concurrently exposed to local anesthetics.
- Articaine + Lidothol Patch— Increased risk of methemoglobinemia with concurrent use of multiple local anesthetics.
- Articaine + Mepivacaine Hydrochloride— Concurrent exposure increases risk of methemoglobinemia in patients administered mepivacaine.
- Articaine + Prilocaine Hcl And Epinephrine— Increased risk of methemoglobinemia when prilocaine is concurrently exposed to articaine.
- Articaine + Prilocaine Hydrochloride— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Articaine + Ropivacaine Hydrochloride— Toxic effects are additive; use with caution in patients receiving other local anesthetics.
- Articaine + Triethanolamine Salicylate— Increased risk of methemoglobinemia when used concurrently with triethanolamine salicylate.
Moderate (7)
- Articaine + Bupivacaine— May increase risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Articaine + Bupivacaine Hydrochloride And Epinephrine Bitartrate— Increased risk of methemoglobinemia when concurrently exposed.
- Articaine + Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine— Additive toxic effects when used with ropivacaine; both are amide-type local anesthetics.
- Articaine + Lidocaine And Tetracaine— Local anesthetic that increases risk of methemoglobinemia when used concomitantly with lidocaine and tetracaine.
- Articaine + Marcaine, Lidocaine, Kenalog, Povidone Iodine— Toxic effects of local anesthetics are additive. Monitor for neurologic and cardiovascular effects when additional local…
- Articaine + Penicillin G Benzathine And Penicillin G Procaine— Increased risk of methemoglobinemia when concurrently exposed with local anesthetics (procaine is a component of this dr…
- Articaine + Triamcinolone Acetonide— Toxic effects of local anesthetics are additive. Monitor for neurologic and cardiovascular effects related to local anes…