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Anagrelide

Also known as: Anagrelide

Route: Oral

20 interactions on record

Anagrelide has 20 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 13 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cilostazol, Milrinone, Acetylsalicylic Acid. Patients taking Anagrelide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 20
Contraindicated: 2
Major: 13
Moderate: 5

Contraindicated (2)

Anagrelide + Cilostazol— Avoid use; both are PDE3 inhibitors with exacerbation of inotropic effects.
Anagrelide + Milrinone— Avoid use; both are PDE3 inhibitors with exacerbation of inotropic effects.

Major (13)

Anagrelide + Acetylsalicylic Acid— Increased risk of major hemorrhagic events; monitor for bleeding and assess hemorrhage risk before initiation.
Anagrelide + Amiodarone— Avoid use; may prolong QT interval and increase risk of arrhythmias with anagrelide.
Anagrelide + Aspirin And Dipyridamole— Patients taking aspirin in combination with anagrelide are at increased risk of bleeding.
Anagrelide + Aspirin And Extended - Release Dipyridamole— Patients taking aspirin with anagrelide are at increased risk of bleeding.
Anagrelide + Asprin And Extended-Release Dipyridamole— Patients taking aspirin with anagrelide are at increased risk of bleeding.
Anagrelide + Chloroquine— Avoid use; may prolong QT interval and increase risk of arrhythmias with anagrelide.
Anagrelide + Clarithromycin— ( 7.3 ) 7.1 Drugs that Prolong QT Avoid use of anagrelide in patients taking medications that may prolong QT interval (i…
Anagrelide + Disopyramide— ( 7.3 ) 7.1 Drugs that Prolong QT Avoid use of anagrelide in patients taking medications that may prolong QT interval (i…
Anagrelide + Haloperidol— Avoid use; may prolong QT interval and increase risk of arrhythmias with anagrelide.
Anagrelide + Methadone— Avoid use; may prolong QT interval and increase risk of arrhythmias with anagrelide.
Anagrelide + Moxifloxacin— ( 7.3 ) 7.1 Drugs that Prolong QT Avoid use of anagrelide in patients taking medications that may prolong QT interval (i…
Anagrelide + Pimozide— Avoid use; may prolong QT interval and increase risk of arrhythmias with anagrelide.
Anagrelide + Procainamide— ( 7.3 ) 7.1 Drugs that Prolong QT Avoid use of anagrelide in patients taking medications that may prolong QT interval (i…

Moderate (5)

Anagrelide + Ciprofloxacin— CYP1A2 inhibitor may increase anagrelide exposure; monitor for cardiovascular events and titrate dose accordingly.
Anagrelide + Fluvoxamine— CYP1A2 inhibitor may increase anagrelide exposure; monitor for cardiovascular events and titrate dose accordingly.
Anagrelide + Omeprazole— CYP1A2 inducer may decrease anagrelide exposure; dose titration may be needed to maintain efficacy.
Anagrelide + Ondansetron— Anagrelide may increase ondansetron exposure as a CYP1A2 substrate; monitor accordingly.
Anagrelide + Theophylline— Anagrelide may increase theophylline exposure as a CYP1A2 substrate; monitor for theophylline toxicity.

Anagrelide + Cilostazol⛔Contraindicated

Avoid use; both are PDE3 inhibitors with exacerbation of inotropic effects.

Anagrelide + Milrinone⛔Contraindicated

Avoid use; both are PDE3 inhibitors with exacerbation of inotropic effects.

Anagrelide + Acetylsalicylic Acid⚠️Major

Increased risk of major hemorrhagic events; monitor for bleeding and assess hemorrhage risk before initiation.

Anagrelide + Amiodarone⚠️Major

Avoid use; may prolong QT interval and increase risk of arrhythmias with anagrelide.

Anagrelide + Aspirin And Dipyridamole⚠️Major

Patients taking aspirin in combination with anagrelide are at increased risk of bleeding.

Anagrelide + Aspirin And Extended - Release Dipyridamole⚠️Major

Patients taking aspirin with anagrelide are at increased risk of bleeding.

Anagrelide + Asprin And Extended-Release Dipyridamole⚠️Major

Patients taking aspirin with anagrelide are at increased risk of bleeding.

Anagrelide + Chloroquine⚠️Major

Avoid use; may prolong QT interval and increase risk of arrhythmias with anagrelide.

Anagrelide + Clarithromycin⚠️Major

( 7.3 ) 7.1 Drugs that Prolong QT Avoid use of anagrelide in patients taking medications that may prolong QT interval (including, but not limited to, chloroquine, clarithromycin, haloperidol, methadone, moxifloxacin, amiodarone, disopyramide, procainamide, and pimozide) [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.2) ] .

Anagrelide + Disopyramide⚠️Major

Anagrelide + Haloperidol⚠️Major

Avoid use; may prolong QT interval and increase risk of arrhythmias with anagrelide.

Anagrelide + Methadone⚠️Major

Avoid use; may prolong QT interval and increase risk of arrhythmias with anagrelide.

Anagrelide + Moxifloxacin⚠️Major

Anagrelide + Pimozide⚠️Major

Avoid use; may prolong QT interval and increase risk of arrhythmias with anagrelide.

Anagrelide + Procainamide⚠️Major

Anagrelide + Ciprofloxacin🟡Moderate

CYP1A2 inhibitor may increase anagrelide exposure; monitor for cardiovascular events and titrate dose accordingly.

Anagrelide + Fluvoxamine🟡Moderate

CYP1A2 inhibitor may increase anagrelide exposure; monitor for cardiovascular events and titrate dose accordingly.

Anagrelide + Omeprazole🟡Moderate

CYP1A2 inducer may decrease anagrelide exposure; dose titration may be needed to maintain efficacy.

Anagrelide + Ondansetron🟡Moderate

Anagrelide may increase ondansetron exposure as a CYP1A2 substrate; monitor accordingly.

Anagrelide + Theophylline🟡Moderate

Anagrelide may increase theophylline exposure as a CYP1A2 substrate; monitor for theophylline toxicity.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.