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Alprostadil

Also known as: Caverject Impulse

Prostaglandin AnalogProstaglandin E1 AgonistProstaglandin Receptor Agonists

Route: Intracavernous

6 interactions on record⛔ Black Box Warning

Alprostadil has 6 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Heparin, Latanoprost, Latanoprost Ophthalmic Solution 0.005%. Patients taking Alprostadil should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 6
Moderate: 4

Moderate (4)

Alprostadil + Heparin— Concomitant administration with alprostadil causes significant increases in partial thromboplastin time (140%) and throm…
Alprostadil + Latanoprost— Combined use of two or more prostaglandins or prostaglandin analogs not recommended. More than once daily administration…
Alprostadil + Latanoprost Ophthalmic Solution 0.005%— Combined use of two or more prostaglandins or prostaglandin analogs not recommended. Administration more than once daily…
Alprostadil + Netarsudil And Latanoprost Ophthalmic Solution, 0.02%/0.005%— Combined use of two or more prostaglandins or analogs including latanoprost is not recommended. Multiple daily administr…

Alprostadil + Heparin🟡Moderate

Concomitant administration with alprostadil causes significant increases in partial thromboplastin time (140%) and thrombin time (120%). Caution should be exercised.

Alprostadil + Latanoprost🟡Moderate

Combined use of two or more prostaglandins or prostaglandin analogs not recommended. More than once daily administration may decrease IOP lowering effect or cause paradoxical IOP elevations.

Alprostadil + Latanoprost Ophthalmic Solution 0.005%🟡Moderate

Combined use of two or more prostaglandins or prostaglandin analogs not recommended. Administration more than once daily may decrease IOP lowering effect or cause paradoxical IOP elevations.

Alprostadil + Netarsudil And Latanoprost Ophthalmic Solution, 0.02%/0.005%🟡Moderate

Combined use of two or more prostaglandins or analogs including latanoprost is not recommended. Multiple daily administration may decrease IOP-lowering effect or cause paradoxical IOP elevations.

Alprostadil + Furosemideℹ️Unknown

Standard therapy includes antibiotics, such as penicillin and gentamicin; vasopressors, such as dopamine and isoproterenol; cardiac glycosides; and diuretics, such as furosemide.

Alprostadil + Penicillinℹ️Unknown

Standard therapy includes antibiotics, such as penicillin and gentamicin; vasopressors, such as dopamine and isoproterenol; cardiac glycosides; and diuretics, such as furosemide.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.