Entacapone has 11 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Epinephrine, Ampicillin, Chloramphenicol. Patients taking Entacapone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 11
- Major
- 1
- Moderate
- 9
Major (1)
- Entacapone + Epinephrine— COMT inhibitor that potentiates pressor effects of epinephrine.
Moderate (9)
- Entacapone + Ampicillin— Ampicillin may interfere with biliary excretion, glucuronidation, and intestinal beta-glucuronidase of entacapone; cauti…
- Entacapone + Chloramphenicol— Chloramphenicol may interfere with biliary excretion, glucuronidation, and intestinal beta-glucuronidase of entacapone; …
- Entacapone + Cholestyramine Light— Cholestyramine may interfere with biliary excretion of entacapone; caution should be exercised when used concurrently.
- Entacapone + Dobutamine— Concomitant use of dobutamine and COMT inhibitors may result in increased heart rate, arrhythmias, and changes in blood …
- Entacapone + Epinephrine In Sodium Chloride— COMT inhibitor that potentiates the effects of epinephrine.
- Entacapone + Erythromycin— Erythromycin may interfere with biliary excretion, glucuronidation, and intestinal beta-glucuronidase of entacapone; cau…
- Entacapone + Probenecid— Probenecid may interfere with biliary excretion of entacapone; caution should be exercised when used concurrently.
- Entacapone + Rifampin— Rifampicin may interfere with biliary excretion, glucuronidation, and intestinal beta-glucuronidase of entacapone; cauti…
- Entacapone + Warfarin— Entacapone may increase R-warfarin AUC by 18% and INR values by 13% on average. Cases of significantly increased INR hav…