Isosorbide Dinitrate Interactions

Brand names: Isosorbide Dinitrate

Nitrate Vasodilator

Route: Oral

Contraindications

CONTRAINDICATIONS Isosorbide dinitrate is contraindicated in patients who are allergic to isosorbide dinitrate or any of its ingredients. Do not use isosorbide dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil. Concomitant use can cause severe hypotension, syncope, or myocardial ischemia. Do not use isosorbide dinitrate in patients who are taking the soluble guanylate cyclase stimulator riociguat. Concomitant use can cause hypotension.

Pregnancy & Breastfeeding

Pregnancy Category C At oral doses 35 and 150 times the maximum recommended human daily dose, isosorbide dinitrate has been shown to cause a dose-related increase in embryotoxicity (increase in mummified pups) in rabbits. There are no adequate, well-controlled studies in pregnant women. Isosorbide dinitrate should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

3 interactions on record

Isosorbide Dinitrate + Mao InhibitorsContraindicated

Concomitant use of isosorbide dinitrate with phosphodiesterase inhibitors in any form is contraindicated.

Source: NLP:isosorbide dinitrate

Isosorbide Dinitrate + RiociguatContraindicated

Concomitant use of isosorbide dinitrate with riociguat, a soluble guanylate cyclase stimulator, is contraindicated.

Source: NLP:isosorbide dinitrate