Isotretinoin has 14 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Doxycycline, Minocycline Hydrochloride, Sarecycline Hydrochloride. Patients taking Isotretinoin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 14
- Contraindicated
- 4
- Major
- 4
- Moderate
- 4
- Minor
- 2
Contraindicated (4)
- Isotretinoin + Doxycycline— Both isotretinoin and tetracyclines can cause increased intracranial pressure and pseudotumor cerebri; concurrent use sh…
- Isotretinoin + Minocycline Hydrochloride— Administration of isotretinoin should be avoided shortly before, during, and shortly after minocycline therapy; both ass…
- Isotretinoin + Sarecycline Hydrochloride— Tetracyclines and oral retinoids both may cause increased intracranial pressure. Avoid coadministration.
- Isotretinoin + Tetracycline— Concomitant use should be avoided due to association with intracranial hypertension (pseudotumor cerebri).
Major (4)
- Isotretinoin + Progesterone— Micro-dosed Progesterone Preparations: Micro-dosed progesterone preparations ("minipills" that do not contain an estroge…
- Isotretinoin + St. John'S Wort— Possible interaction with hormonal contraceptives; reports of breakthrough bleeding and pregnancies in users of combined…
- Isotretinoin + Valoctocogene Roxaparvovec-Rvox— Decreased factor VIII activity without ALT elevation detected after starting isotretinoin. Factor VIII activity transien…
- Isotretinoin + Vitamin A— Additive toxic effects due to relationship of isotretinoin to vitamin A. Patients should avoid vitamin supplements conta…
Moderate (4)
- Isotretinoin + Corticosteroids— Caution should be exercised when using together due to potential additive effects on bone loss.
- Isotretinoin + Norethindrone And Ethinyl Estradiol— Study showed isotretinoin did not induce clinically relevant pharmacokinetic changes; however, effectiveness as contrace…
- Isotretinoin + Phenytoin— Caution should be exercised when using together due to potential additive effects on bone loss.
- Isotretinoin + Prenatal Multivitamin Tablet And Combination Omega-3 Softgel/Mineral Capsule— Reduced folate levels have occurred in some patients taking isotretinoin.
Minor (2)
- Isotretinoin + Ethinyl Estradiol— Clinical trial showed no clinically relevant changes in pharmacokinetics or hormone levels at recommended isotretinoin d…
- Isotretinoin + Norethindrone— Clinical trial showed no clinically relevant changes in pharmacokinetics or hormone levels at recommended isotretinoin d…