Kanamycin has 8 known drug interactions based on U.S. FDA drug labeling data. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Gentamicin Sulfate, Neostigmine Methylsulfate, Pyridostigmine Bromide. Patients taking Kanamycin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 8
- Major
- 4
- Moderate
- 3
Major (4)
- Kanamycin + Gentamicin Sulfate— Concurrent and/or sequential use should be avoided due to potential neurotoxicity and nephrotoxicity.
- Kanamycin + Neostigmine Methylsulfate— Kanamycin has nondepolarizing neuromuscular blocking action; neostigmine dose adjustments may be required to reverse neu…
- Kanamycin + Pyridostigmine Bromide— Parenteral administration may intensify or produce neuromuscular block and paralysis when used with pyridostigmine.
- Kanamycin + Vecuronium Bromide— Kanamycin may intensify or produce neuromuscular block on its own and can cause unexpected prolongation of vecuronium-in…
Moderate (3)
- Kanamycin + Ascorbic Acid— Ascorbic acid may decrease the activity of kanamycin. Standard monitoring of antibiotic efficacy is warranted.
- Kanamycin + Ascorbic Acid, Vitamin A Palmitate, Cholecalciferol, Thiamine Hydrochloride, Riboflavin-5 Phosphate Sodium, Pyridoxine Hydrochloride, Niacinamide, Dexpanthenol, Alpha-Tocopherol Acetate, Vitamin K1, Folic Acid, Biotin, Cyanocobalamin— Thiamine, riboflavin, pyridoxine, niacinamide, and ascorbic acid decrease the antibiotic activity of kanamycin.
- Kanamycin + Multiple Vitamins Injection— Thiamine, riboflavin, pyridoxine, niacinamide, and ascorbic acid decrease kanamycin antibiotic activity.