Aluminum Hydroxide has 22 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Ciprofloxacin, Sodium Polystyrene Sulfonate, Cefaclor. Patients taking Aluminum Hydroxide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 22
- Major
- 2
- Moderate
- 20
Major (2)
- Aluminum Hydroxide + Ciprofloxacin— Concurrent administration may reduce ciprofloxacin bioavailability by as much as 90%.
- Aluminum Hydroxide + Sodium Polystyrene Sulfonate— Intestinal obstruction due to concretions has been reported when used in combination with sodium polystyrene sulfonate.
Moderate (20)
- Aluminum Hydroxide + Cefaclor— Aluminum hydroxide-containing antacids diminish the extent of absorption of cefaclor extended-release tablets if taken w…
- Aluminum Hydroxide + Cefpodoxime Proxetil— High doses reduce peak plasma levels by 24-42% and extent of absorption by 27-32%, but do not alter absorption rate.
- Aluminum Hydroxide + Doxycycline Hyclate— Antacids containing aluminum impair absorption of tetracyclines.
- Aluminum Hydroxide + Ethambutol Hydrochloride— Aluminum hydroxide reduces ethambutol oral absorption, decreasing serum concentrations by ~20% and urinary excretion by …
- Aluminum Hydroxide + Fosinopril— Antacid reduces serum levels and urinary excretion of fosinoprilat. Separate dosing by 2 hours if concomitant use is nee…
- Aluminum Hydroxide + Fosinopril Sodium— Reduces serum levels and urinary excretion of fosinoprilat. Dosing should be separated by 2 hours.
- Aluminum Hydroxide + Fosinopril Sodium And Hydrochlorothiazide— Antacid may impair absorption of fosinopril; dosing should be separated by 2 hours if concomitant use is necessary.
- Aluminum Hydroxide + Gabapentin— Antacid containing aluminum hydroxide and magnesium hydroxide reduced gabapentin immediate release bioavailability by ap…
- Aluminum Hydroxide + Itraconazole— Reduces gastric acidity and impairs itraconazole absorption from capsules. Administer at least 1 hour before or 2 hours …
- Aluminum Hydroxide + Ketoconazole— Reduces gastric acidity and impairs ketoconazole absorption from tablets. Should be administered at least 1 hour before …
- Aluminum Hydroxide + Levothyroxine Sodium— Antacid that may affect intragastric pH and reduce levothyroxine absorption. Monitor patients appropriately.
- Aluminum Hydroxide + Mycophenilic Acid— Decreases concentrations of mycophenolic acid; concomitant use is not recommended.
- Aluminum Hydroxide + Mycophenolate Mofetil— Decreases mycophenolate mofetil systemic exposure and may reduce efficacy. Administer at least 2 hours after mycophenola…
- Aluminum Hydroxide + Mycophenolate Mofetil Hydrochloride— Decreases mycophenolic acid systemic exposure and may reduce Mycophenolate Mofetil efficacy. Administer at least 2 hours…
- Aluminum Hydroxide + Naproxen— Concomitant administration can delay the absorption of naproxen.
- Aluminum Hydroxide + Phenytoin— May decrease phenytoin serum levels by affecting absorption; should not be taken at same time.
- Aluminum Hydroxide + Phenytoin Sodium— May decrease phenytoin serum levels by affecting absorption; should not be taken at the same time of day.
- Aluminum Hydroxide + Rilpivirine— Concomitant intake may cause significant decreases in rilpivirine plasma concentrations. Administer at least 2 hours bef…
- Aluminum Hydroxide + Rilpivirine Hydrochloride— Coadministration may cause significant decreases in rilpivirine plasma concentrations due to increase in gastric pH. Ant…
- Aluminum Hydroxide + Riociguat— Separate administration by at least 1 hour.