Ketamine has 9 known drug interactions based on U.S. FDA drug labeling data. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Levothyroxine Sodium, Levothyroxine Sodium Anhydrous, Midazolam Hydrochloride. Patients taking Ketamine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 9
- Major
- 4
- Moderate
- 5
Major (4)
- Ketamine + Levothyroxine Sodium— Concurrent use may produce marked hypertension and tachycardia. Closely monitor blood pressure and heart rate in these p…
- Ketamine + Levothyroxine Sodium Anhydrous— Concurrent use may produce marked hypertension and tachycardia. Cautious administration to patients receiving thyroid ho…
- Ketamine + Midazolam Hydrochloride— CNS depressant that accentuates the sedative effect of midazolam, requiring dose adjustment.
- Ketamine + Probenecid— Ketamine anesthesia is significantly prolonged in patients receiving probenecid.
Moderate (5)
- Ketamine + Liothyronine Sodium— When administered to patients on thyroid preparation, this parenteral anesthetic may cause hypertension and tachycardia.…
- Ketamine + Memantine— Combined use of memantine with ketamine has not been systematically evaluated and should be approached with caution due …
- Ketamine + Memantine Hydrochloride— Combined use with memantine has not been systematically evaluated. Both are NMDA antagonists and such use should be appr…
- Ketamine + Memantine Hydrochloride And Donepezil Hydrochloride— Combined use of memantine with ketamine (NMDA antagonist) has not been systematically evaluated and should be approached…
- Ketamine + Probenecid And Colchicine— Probenecid significantly prolongs ketamine anesthesia.