Ketoprofen has 14 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Lithium, Methotrexate, Sulopenem Etzadroxil And Probenecid. Patients taking Ketoprofen should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 14
- Major
- 3
- Moderate
- 11
Major (3)
- Ketoprofen + Lithium— NSAIDs elevate plasma lithium levels and reduce renal lithium clearance by approximately 20%, increasing lithium toxicit…
- Ketoprofen + Methotrexate— Ketoprofen may alter methotrexate elimination leading to elevated serum levels and increased toxicity. NSAIDs may compet…
- Ketoprofen + Sulopenem Etzadroxil And Probenecid— Probenecid inhibits OAT1/3, increasing ketoprofen plasma concentrations. Concomitant use is not recommended.
Moderate (11)
- Ketoprofen + Acetylsalicylic Acid— Concurrent aspirin decreases ketoprofen protein binding and increases plasma clearance. Concomitant use is not generally…
- Ketoprofen + Caffeine Citrate— Concurrent use reduced urine volume in healthy volunteers; clinical significance in preterm neonates unknown.
- Ketoprofen + Furosemide— NSAIDs can reduce the natriuretic effect of furosemide in some patients. Patients are at greater risk of renal failure s…
- Ketoprofen + Hydrochlorothiazide— Concomitant administration produces reduction in urinary potassium and chloride excretion. Patients at greater risk of r…
- Ketoprofen + Leflunomide— Exposure to ketoprofen may be increased when coadministered with leflunomide. Monitor and adjust dose as required.
- Ketoprofen + Leflunomide And Diclofenac Sodium Gel— Exposure of ketoprofen may be increased in patients taking leflunomide. Monitor and adjust dose as required.
- Ketoprofen + Mao Inhibitors— NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. This interaction should be given consideration in pat…
- Ketoprofen + Probenecid— Probenecid increases plasma elimination half-life and concentrations of ketoprofen; lower dosage may be required.
- Ketoprofen + Probenecid And Colchicine— Probenecid increases mean plasma elimination half-life and plasma concentrations of ketoprofen; use lower dosages cautio…
- Ketoprofen + Teriflunomide— Teriflunomide may increase exposure of ketoprofen. Monitor patients and adjust dose as required.
- Ketoprofen + Thiazides— NSAIDs can reduce the natriuretic effect of thiazides in some patients. Patients are at greater risk of renal failure se…