Both digitalis glycosides and labetalol slow atrioventricular conduction and decrease heart rate; concomitant use increases risk of bradycardia.
Source: NLP:labetalol
Labetalol Interactions
Brand names: Labetalol Hydrochloride
beta-Adrenergic Blocker · Adrenergic beta-Antagonists
Route: Oral
Contraindications
CONTRAINDICATIONS Labetalol hydrochloride is contraindicated in bronchial asthma, overt cardiac failure, greater-than-first- degree heart block, cardiogenic shock, severe bradycardia, other conditions associated with severe and prolonged hypotension, and in patients with a history of hypersensitivity to any component of the product [see Warnings ] . Beta-blockers, even those with apparent cardioselectivity, should not be used in patients with a history of obstructive airway disease, including asthma.
Pregnancy & Breastfeeding
Pregnancy Teratogenic Effects Pregnancy Category C Teratogenic studies were performed with labetalol in rats and rabbits at oral doses up to approximately six and four times the maximum recommended human dose (MRHD), respectively. No reproducible evidence of fetal malformations was observed. Increased fetal resorptions were seen in both species at doses approximating the MRHD. A teratology study performed with labetalol in rabbits at intravenous doses up to 1.7 times the MRHD revealed no evidence of drug-related harm to the fetus. There are no adequate and well-controlled studies in pregnant women. Labetalol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Nonteratogenic Effects Hypotension, bradycardia, hypoglycemia, and respiratory depression have been reported in infants of mothers who were treated with labetalol hydrochloride for hypertension during pregnancy. Oral administration of labetalol to rats during late gestation through weaning at doses of two to four times the MRHD caused a decrease in neonatal survival.
8 interactions on record
Patients taking labetalol may be unresponsive to usual epinephrine doses for treating allergic reactions, particularly those with history of severe anaphylactic reactions.
Source: NLP:labetalol
Synergism between halothane anesthesia and intravenous labetalol increases hypotension and risks of reduced cardiac output and increased central venous pressure. High halothane concentrations (≥3%) should be avoided.
Source: NLP:labetalol
Labetalol + CimetidineModerate
Cimetidine increases labetalol bioavailability, requiring special care in dose adjustment for blood pressure control.
Source: NLP:labetalol
Labetalol + NicotineModerate
Smoking cessation with nicotine replacement may require dose decrease due to decreased circulating catecholamines.
Source: NLP:nicotine
Labetalol + NitroglycerinModerate
Labetalol blunts reflex tachycardia from nitroglycerin and may produce additional antihypertensive effects when used concomitantly in angina patients.
Source: NLP:labetalol
Labetalol can blunt the bronchodilator effect of beta-agonists in patients with bronchospasm; higher than normal anti-asthmatic doses may be required.
Source: NLP:labetalol
Labetalol + VerapamilModerate
Care should be taken when using labetalol concomitantly with verapamil, a calcium antagonist.
Source: NLP:labetalol