Labetalol has 9 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Digitalis Glycosides, Epinephrine, Halothane. Patients taking Labetalol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 9
- Major
- 3
- Moderate
- 6
Major (3)
- Labetalol + Digitalis Glycosides— Both digitalis glycosides and labetalol slow atrioventricular conduction and decrease heart rate; concomitant use increa…
- Labetalol + Epinephrine— Patients taking labetalol may be unresponsive to usual epinephrine doses for treating allergic reactions, particularly t…
- Labetalol + Halothane— Synergism between halothane anesthesia and intravenous labetalol increases hypotension and risks of reduced cardiac outp…
Moderate (6)
- Labetalol + Cimetidine— Cimetidine increases labetalol bioavailability, requiring special care in dose adjustment for blood pressure control.
- Labetalol + Iobenguane I-123— Antihypertensive that depletes norepinephrine stores or inhibits reuptake, potentially decreasing iobenguane uptake and …
- Labetalol + Nicotine— Smoking cessation with nicotine replacement may require dose decrease due to decreased circulating catecholamines.
- Labetalol + Nitroglycerin— Labetalol blunts reflex tachycardia from nitroglycerin and may produce additional antihypertensive effects when used con…
- Labetalol + Nonselective Beta-Adrenergic Antagonists— Labetalol can blunt the bronchodilator effect of beta-agonists in patients with bronchospasm; higher than normal anti-as…
- Labetalol + Verapamil— Care should be taken when using labetalol concomitantly with verapamil, a calcium antagonist.