Amantadine has 26 known drug interactions based on U.S. FDA drug labeling data. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Bupropion, Bupropion Hcl Er, Bupropion Hydrobromide. Patients taking Amantadine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 26
- Major
- 7
- Moderate
- 19
Major (7)
- Amantadine + Bupropion— Dopaminergic drug; concomitant use with bupropion can cause CNS toxicity; use with caution.
- Amantadine + Bupropion Hcl Er— CNS toxicity can occur when used concomitantly with bupropion.
- Amantadine + Bupropion Hydrobromide— CNS toxicity can occur when used concomitantly with bupropion. Use with caution.
- Amantadine + Bupropion Hydrochloride— Dopaminergic drug. CNS toxicity can occur when used concomitantly with bupropion.
- Amantadine + Glycopyrrolate— Potential for additive anticholinergic interaction resulting in increased anticholinergic adverse reactions.
- Amantadine + Live Attenuated Vaccines— Amantadine's antiviral properties may interfere with vaccine efficacy. Live vaccines are not recommended during treatmen…
- Amantadine + Sulfamethoxazole And Trimethoprim— Toxic delirium reported after concomitant intake of BACTRIM and amantadine, an OCT2 substrate.
Moderate (19)
- Amantadine + Acidifying Agents— Agents with anticholinergic properties may potentiate the anticholinergic-like side effects of amantadine.
- Amantadine + Alcohol— Concomitant use may increase CNS effects (dizziness, confusion, lightheadedness, orthostatic hypotension) and result in …
- Amantadine + Cns Stimulants— Careful observation required when administered concurrently with amantadine due to potential CNS effects.
- Amantadine + Dicyclomine Hydrochloride— May increase certain actions or side effects of anticholinergic drugs including dicyclomine hydrochloride.
- Amantadine + Glycopyrrolate Oral Solution— Anticholinergic effects of glycopyrrolate may be increased with concomitant amantadine administration. Consider decreasi…
- Amantadine + Hydrochlorothiazide— Coadministration resulted in higher plasma amantadine concentration; monitor amantadine levels.
- Amantadine + Hyoscyamine Sulfate— Additive adverse effects from cholinergic blockade may occur when combined with hyoscyamine sulfate.
- Amantadine + Mao Inhibitors— Alters urine pH toward acidic conditions, increasing amantadine elimination and reducing efficacy. Monitor for decreased…
- Amantadine + Memantine— Combined use of memantine with amantadine has not been systematically evaluated and should be approached with caution du…
- Amantadine + Memantine Hydrochloride— Combined use with memantine has not been systematically evaluated. Both are NMDA antagonists and such use should be appr…
- Amantadine + Memantine Hydrochloride And Donepezil Hydrochloride— Combined use of memantine with amantadine (NMDA antagonist) has not been systematically evaluated and should be approach…
- Amantadine + Naltrexone Hydrochloride And Bupropion Hydrochloride— Dopaminergic drug that can cause CNS toxicity when used concomitantly with CONTRAVE. Dose with caution.
- Amantadine + Other Anticholinergic Agents— Anticholinergic drugs may potentiate anticholinergic-like side effects of amantadine. Dose reduction recommended if atro…
- Amantadine + Quinidine— Reduces renal clearance of amantadine by approximately 30%.
- Amantadine + Quinine— Reduces renal clearance of amantadine by approximately 30%.
- Amantadine + Sodium Bicarbonate— Alters urine pH toward alkaline conditions, potentially leading to amantadine accumulation and increased adverse reactio…
- Amantadine + Thioridazine— Coadministration has been reported to worsen tremor in elderly patients with Parkinson's disease.
- Amantadine + Triamterene— Coadministration resulted in higher plasma amantadine concentration; monitor amantadine levels.
- Amantadine + Triamterene And Hydrochlorothiazide— Coadministration resulted in higher plasma amantadine concentrations; monitoring recommended.