Lactulose has 4 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Antacids Containing Calcium, Anti-Infective Agents, Laxatives. Patients taking Lactulose should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 4
- Moderate
- 4
Moderate (4)
- Lactulose + Antacids Containing Calcium— Nonabsorbable antacids may inhibit the lactulose-induced drop in colonic pH, potentially reducing treatment efficacy. Mo…
- Lactulose + Anti-Infective Agents— Anti-infective agents may interfere with the desired degradation of lactulose and acidification of colonic contents. Pat…
- Lactulose + Laxatives— Other laxatives should not be used concomitantly, especially during initial therapy for portal-systemic encephalopathy, …
- Lactulose + Neomycin— Elimination of colonic bacteria by neomycin may interfere with lactulose degradation and prevent acidification of coloni…