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Lactulose

Also known as: Constulose, Enulose, Generlac, Kristalose

Osmotic LaxativeOsmotic ActivityAcidifying Activity

Route: Oral

4 interactions on record

Lactulose has 4 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Antacids Containing Calcium, Anti-Infective Agents, Laxatives. Patients taking Lactulose should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 4
Moderate: 4

Moderate (4)

Lactulose + Antacids Containing Calcium— Nonabsorbable antacids may inhibit the lactulose-induced drop in colonic pH, potentially reducing treatment efficacy. Mo…
Lactulose + Anti-Infective Agents— Anti-infective agents may interfere with the desired degradation of lactulose and acidification of colonic contents. Pat…
Lactulose + Laxatives— Other laxatives should not be used concomitantly, especially during initial therapy for portal-systemic encephalopathy, …
Lactulose + Neomycin— Elimination of colonic bacteria by neomycin may interfere with lactulose degradation and prevent acidification of coloni…

Lactulose + Antacids Containing Calcium🟡Moderate

Nonabsorbable antacids may inhibit the lactulose-induced drop in colonic pH, potentially reducing treatment efficacy. Monitor for lack of desired effect.

Lactulose + Anti-Infective Agents🟡Moderate

Anti-infective agents may interfere with the desired degradation of lactulose and acidification of colonic contents. Patient status should be closely monitored.

Lactulose + Laxatives🟡Moderate

Other laxatives should not be used concomitantly, especially during initial therapy for portal-systemic encephalopathy, as loose stools may falsely suggest adequate dosage.

Lactulose + Neomycin🟡Moderate

Elimination of colonic bacteria by neomycin may interfere with lactulose degradation and prevent acidification of colonic contents. Close monitoring recommended during concomitant use.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.