Lidocaine has 60 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 46 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Bupivacaine, Acetaminophen, Acetazolamide. Patients taking Lidocaine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 60
- Contraindicated
- 1
- Major
- 46
- Moderate
- 12
- Minor
- 1
Contraindicated (1)
- Lidocaine + Bupivacaine— Do not admix with bupivacaine liposome injectable suspension; causes immediate release of bupivacaine from liposomal par…
Major (46)
- Lidocaine + Acetaminophen— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Acetazolamide— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Articaine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Articaine Hydrochloride And Epinephrine— Increased risk of methemoglobinemia when concurrently exposed with articaine and other local anesthetics.
- Lidocaine + Articaine Hydrochloride And Epinephrine Bitartrate— Increased risk of developing methemoglobinemia when concurrently exposed to this local anesthetic.
- Lidocaine + Benzocaine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Bupivacaine And Meloxicam— Toxic effects of local anesthetics are additive. Avoid additional local anesthetics within 96 hours of ZYNRELEF; if unav…
- Lidocaine + Bupivacaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Lidocaine + Chloroquine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Cimetidine— Cimetidine reduces hepatic metabolism of lidocaine, delaying elimination and increasing blood levels. Adverse clinical e…
- Lidocaine + Cimetidine Hydrochloride— Cimetidine reduces hepatic metabolism of lidocaine, increasing blood levels with reported adverse clinical effects.
- Lidocaine + Cyclophosphamide— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Dapsone— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Disopyramide Phosphate— Concurrent antiarrhythmic use may cause excessive QRS widening and/or Q-T prolongation.
- Lidocaine + Flutamide— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Hydroxyurea— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Ifosfamide— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Mepivacaine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Mepivacaine Hydrochloride— Concurrent exposure increases risk of methemoglobinemia in patients administered mepivacaine.
- Lidocaine + Metoclopramide— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Mexiletine— Class I antiarrhythmic; toxic effects are additive and potentially synergistic when used with lidocaine patch 5%.
- Lidocaine + Nitric Oxide— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Nitrofurantoin— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Nitroglycerin— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Nitroprusside— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Nitrous Oxide— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Para-Aminosalicylic Acid— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Phenobarbital— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Phenytoin— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Prilocaine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Prilocaine Hcl And Epinephrine— Increased risk of methemoglobinemia when prilocaine is concurrently exposed to lidocaine.
- Lidocaine + Prilocaine Hydrochloride— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Lidocaine + Primaquine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Procaine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Propranolol Hydrochloride— Propranolol reduces lidocaine clearance and lidocaine toxicity has been reported following coadministration.
- Lidocaine + Quinine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Rasburicase— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Ropivacaine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Ropivacaine Hydrochloride— Toxic effects are additive; use with caution in patients receiving other local anesthetics.
- Lidocaine + Succinylcholine Chloride— May enhance the neuromuscular blocking action of succinylcholine.
- Lidocaine + Sulfasalazine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Tetracaine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Lidocaine + Tocainide— Class I antiarrhythmic; toxic effects are additive and potentially synergistic when used with lidocaine patch 5%.
- Lidocaine + Triethanolamine Salicylate— Increased risk of methemoglobinemia when used concurrently with triethanolamine salicylate.
- Lidocaine + Trubrexa Patch Er— Increased risk of methemoglobinemia when used with Trubrexa Transdermal Patch; total amount absorbed from all formulatio…
- Lidocaine + Valproate Sodium— Increased risk of methemoglobinemia when used concurrently with lidocaine.
Moderate (12)
- Lidocaine + Amiodarone Hydrochloride— CYP3A substrate. Sinus bradycardia reported with oral amiodarone and lidocaine for local anesthesia. Monitor heart rate;…
- Lidocaine + Bupivacaine Hydrochloride And Epinephrine Bitartrate— Increased risk of methemoglobinemia when concurrently exposed.
- Lidocaine + Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine— Additive toxic effects and increased methemoglobinemia risk when used with ropivacaine.
- Lidocaine + Nirmatrelvir And Ritonavir— Caution warranted and therapeutic concentration monitoring recommended for systemic lidocaine.
- Lidocaine + Other Products Containing Local Anesthetic Agents— When lidocaine patch 5% is used concomitantly with other local anesthetic products, the amount absorbed from all formula…
- Lidocaine + Para-Aminosalicyclic Acid— Antibiotic. Increases risk of methemoglobinemia when used concomitantly with lidocaine.
- Lidocaine + Penicillin G Benzathine And Penicillin G Procaine— Increased risk of methemoglobinemia when concurrently exposed with local anesthetics (procaine is a component of this dr…
- Lidocaine + Propafenone— Concomitant use may increase central nervous system side effects.
- Lidocaine + Propafenone Hydrochloride— Concomitant use may increase central nervous system side effects.
- Lidocaine + Raloxifene— Use with caution; raloxifene is highly protein-bound and may affect protein binding of lidocaine.
- Lidocaine + Raloxifene Hydrochloride— Use with caution. Highly protein-bound drug; raloxifene is >95% protein-bound and may affect protein binding of lidocain…
- Lidocaine + Succinylcholine— May enhance the neuromuscular blocking action of succinylcholine.
Minor (1)
- Lidocaine + Phentolamine Mesylate— Lidocaine concentration increased immediately after phentolamine mesylate intraoral injection, but AUC and Cmax values w…