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Loperamide

Also known as: Imodium Multi-Symptom Relief, Imodium, Diamode, Imodium Advanced

6 interactions on record

Loperamide has 6 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Lonafarnib, Eluxadoline, Gemfibrozil. Patients taking Loperamide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 6
Contraindicated: 1
Major: 1
Moderate: 3

Contraindicated (1)

Loperamide + Lonafarnib— Loperamide Clinical Impact Lonafarnib is a weak inhibitor of P-gp and strong inhibitor of CYP3A. Coadministration of ZOK…

Major (1)

Loperamide + Eluxadoline— Examples: cyclosporine, gemfibrozil, antiretrovirals (atazanavir, lopinavir, ritonavir, saquinavir, tipranavir), rifampi…

Moderate (3)

Loperamide + Gemfibrozil— Gemfibrozil is a strong CYP2C8 inhibitor that may increase loperamide exposure; dosing reduction may be required.
Loperamide + Itraconazole— Aprepitant Loperamide a Monitor for adverse reactions.
Loperamide + Loperamide Hydrochloride— Drug Interactions Nonclinical data have shown that loperamide is a P-glycoprotein substrate. Concomitant administration …

Loperamide + Lonafarnib⛔Contraindicated

Loperamide Clinical Impact Lonafarnib is a weak inhibitor of P-gp and strong inhibitor of CYP3A. Coadministration of ZOKINVY with loperamide increases the AUC and C max of loperamide [see Clinical Pharmacology ( 12.3 )] which may increase the risk of loperamide's adverse reactions. Prevention or Management Loperamide is contraindicated in patients less than 2 years of age.

Loperamide + Eluxadoline⚠️Major

Examples: cyclosporine, gemfibrozil, antiretrovirals (atazanavir, lopinavir, ritonavir, saquinavir, tipranavir), rifampin, eltrombopag Drugs that Cause Constipation Clinical Impact: Increased risk for constipation related adverse reactions and potential for constipation related serious adverse reactions Intervention: Avoid use with other drugs that may cause constipation (see below); loperamide may be used occasionally for acute management of severe diarrhea but avoid chronic use. Discontinue loperamide immediately if constipation occurs.

Loperamide + Gemfibrozil🟡Moderate

Gemfibrozil is a strong CYP2C8 inhibitor that may increase loperamide exposure; dosing reduction may be required.

Loperamide + Itraconazole🟡Moderate

Aprepitant Loperamide a Monitor for adverse reactions.

Loperamide + Loperamide Hydrochloride🟡Moderate

Drug Interactions Nonclinical data have shown that loperamide is a P-glycoprotein substrate. Concomitant administration of loperamide (16 mg single dose) with a 600 mg single dose of either quinidine or ritonavir, both of which are P-glycoprotein inhibitors, resulted in a 2 to 3 fold increase in loperamide plasma levels. Due to the potential for enhanced central effects when loperamide is coadministered with quinidine and with ritonavir, caution should be exercised when loperamide is administered at the recommended dosages (2 mg, up to 16 mg maximum daily dose) with P-glycoprotein inhibitors.

Loperamide + Posaconazoleℹ️Unknown

No clinically relevant effects on the pharmacokinetics of Noxafil oral suspension were observed during concomitant use with antacids, H 2 -receptor antagonists (other than cimetidine), and loperamide [see Clinical Pharmacology (12.3) ] .

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.