Temsirolimus has 12 known drug interactions based on U.S. FDA drug labeling data. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Benazepril Hydrochloride And Hydrochlorothiazide, Carbamazepine, Fosinopril. Patients taking Temsirolimus should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 12
- Major
- 6
- Moderate
- 5
Major (6)
- Temsirolimus + Benazepril Hydrochloride And Hydrochlorothiazide— mTOR inhibitor coadministration with ACE inhibitor may increase risk for angioedema.
- Temsirolimus + Carbamazepine— Use of carbamazepine with temsirolimus should be avoided due to significant reduction in temsirolimus concentrations. If…
- Temsirolimus + Fosinopril— mTOR inhibitor that may increase risk of angioedema when used concomitantly with fosinopril.
- Temsirolimus + Fosinopril Sodium— Patients taking concomitant mTOR inhibitor therapy may be at increased risk for angioedema.
- Temsirolimus + Quinapril— Patients taking mTOR inhibitor therapy may be at increased risk for angioedema when combined with quinapril.
- Temsirolimus + Ramipril— Patients taking concomitant mTOR inhibitor therapy may be at increased risk for angioedema.
Moderate (5)
- Temsirolimus + Amlodipine— 7.3 Angioedema with ACE inhibitors and Calcium Channel Blockers Angioedema has been reported in patients taking mammalia…
- Temsirolimus + Benazepril Hydrochloride— mTOR inhibitor; coadministration with ACE inhibitors requires monitoring.
- Temsirolimus + Ketoconazole— Potent CYP3A4 inhibitor increases sirolimus (primary metabolite) AUC 3.1-fold and Cmax 2.2-fold. Dose adjustment of tems…
- Temsirolimus + Quinapril Hydrochloride— Concomitant mTOR inhibitor therapy may increase risk of angioedema in patients taking quinapril.
- Temsirolimus + Rifampin— Potent CYP3A4/5 inducer decreases sirolimus (primary metabolite) Cmax by 65% and AUC by 56%. Dose adjustment of temsirol…