Magnesium Hydroxide has 19 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Sodium Polystyrene Sulfonate, Ciprofloxacin, Cefaclor. Patients taking Magnesium Hydroxide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 19
- Contraindicated
- 1
- Major
- 1
- Moderate
- 17
Contraindicated (1)
- Magnesium Hydroxide + Sodium Polystyrene Sulfonate— Should not be administered with sodium polystyrene sulfonate. Risk of systemic alkalosis and seizures reported.
Major (1)
- Magnesium Hydroxide + Ciprofloxacin— Concurrent administration may reduce ciprofloxacin bioavailability by as much as 90%.
Moderate (17)
- Magnesium Hydroxide + Cefaclor— Magnesium hydroxide-containing antacids diminish the extent of absorption of cefaclor extended-release tablets if taken …
- Magnesium Hydroxide + Doxycycline Hyclate— Antacids containing magnesium impair absorption of tetracyclines.
- Magnesium Hydroxide + Fosinopril— Antacid reduces serum levels and urinary excretion of fosinoprilat. Separate dosing by 2 hours if concomitant use is nee…
- Magnesium Hydroxide + Fosinopril Sodium— Reduces serum levels and urinary excretion of fosinoprilat. Dosing should be separated by 2 hours.
- Magnesium Hydroxide + Fosinopril Sodium And Hydrochlorothiazide— Antacid may impair absorption of fosinopril; dosing should be separated by 2 hours if concomitant use is necessary.
- Magnesium Hydroxide + Gabapentin— Antacid containing aluminum hydroxide and magnesium hydroxide reduced gabapentin immediate release bioavailability by ap…
- Magnesium Hydroxide + Levothyroxine Sodium— Antacid that may affect intragastric pH and reduce levothyroxine absorption. Monitor patients appropriately.
- Magnesium Hydroxide + Mefenamic Acid— Antacid containing magnesium hydroxide increased mefenamic acid Cmax by 125% and AUC by 36% in a single dose study.
- Magnesium Hydroxide + Mycophenilic Acid— Decreases concentrations of mycophenolic acid; concomitant use is not recommended.
- Magnesium Hydroxide + Mycophenolate Mofetil— Decreases mycophenolate mofetil systemic exposure and may reduce efficacy. Administer at least 2 hours after mycophenola…
- Magnesium Hydroxide + Mycophenolate Mofetil Hydrochloride— Decreases mycophenolic acid systemic exposure and may reduce Mycophenolate Mofetil efficacy. Administer at least 2 hours…
- Magnesium Hydroxide + Phenytoin— May decrease phenytoin serum levels by affecting absorption; should not be taken at same time.
- Magnesium Hydroxide + Phenytoin Sodium— May decrease phenytoin serum levels by affecting absorption; should not be taken at the same time of day.
- Magnesium Hydroxide + Rilpivirine— Concomitant intake may cause significant decreases in rilpivirine plasma concentrations. Administer at least 2 hours bef…
- Magnesium Hydroxide + Rilpivirine Hydrochloride— Coadministration may cause significant decreases in rilpivirine plasma concentrations due to increase in gastric pH. Ant…
- Magnesium Hydroxide + Riociguat— Separate administration by at least 1 hour.
- Magnesium Hydroxide + Sotalol Hydrochloride— Reduces sotalol exposure; avoid administration of oral sotalol within 2 hours of antacids containing magnesium hydroxide…