Dorzolamide Hydrochloride And Timolol Maleate Preservative Free has 14 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Beta-Adrenergic Blocking Agents (Topical), Mao Inhibitors, Aspirin (High-Dose). Patients taking Dorzolamide Hydrochloride And Timolol Maleate Preservative Free should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 14
- Contraindicated
- 2
- Major
- 5
- Moderate
- 5
Contraindicated (2)
- Dorzolamide Hydrochloride And Timolol Maleate Preservative Free + Beta-Adrenergic Blocking Agents (Topical)— Concomitant use of two topical beta-adrenergic blocking agents is not recommended.
- Dorzolamide Hydrochloride And Timolol Maleate Preservative Free + Mao Inhibitors— Potential additive effect on known systemic effects of carbonic anhydrase inhibition. Concomitant administration is not …
Major (5)
- Dorzolamide Hydrochloride And Timolol Maleate Preservative Free + Aspirin (High-Dose)— Potential for acid-base and electrolyte disturbances that may result in salicylate toxicity, as reported with oral carbo…
- Dorzolamide Hydrochloride And Timolol Maleate Preservative Free + Calcium Antagonists— Caution advised; may cause atrioventricular conduction disturbances, left ventricular failure, and hypotension. Avoid in…
- Dorzolamide Hydrochloride And Timolol Maleate Preservative Free + Nonselective Beta-Adrenergic Antagonists— Oral beta-blockers with dorzolamide/timolol may produce additive systemic beta-blockade effects. Concomitant topical bet…
- Dorzolamide Hydrochloride And Timolol Maleate Preservative Free + Oral Beta-Adrenergic Blocking Agents— Potential additive effects of beta-blockade, both systemic and on intraocular pressure. Concomitant use of two topical b…
- Dorzolamide Hydrochloride And Timolol Maleate Preservative Free + Reserpine— Catecholamine-depleting drug with additive effects; may produce hypotension and/or marked bradycardia, leading to vertig…
Moderate (5)
- Dorzolamide Hydrochloride And Timolol Maleate Preservative Free + Clonidine— Oral beta-adrenergic blocking agents may exacerbate rebound hypertension.
- Dorzolamide Hydrochloride And Timolol Maleate Preservative Free + Digitalis Glycosides— May have additive effects in prolonging atrioventricular conduction time.
- Dorzolamide Hydrochloride And Timolol Maleate Preservative Free + High-Dose Salicylate Therapy— Potential for acid-base and electrolyte disturbances that may result in salicylate toxicity, as reported with oral carbo…
- Dorzolamide Hydrochloride And Timolol Maleate Preservative Free + Quinidine— CYP2D6 inhibitor may potentiate systemic beta-blockade, causing decreased heart rate and depression.
- Dorzolamide Hydrochloride And Timolol Maleate Preservative Free + Salicylates— Potential for acid-base and electrolyte disturbances and toxicity with high-dose salicylate therapy.