Mefloquine has 7 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Pimozide, Quinine Sulfate, Chloroquine Phosphate. Patients taking Mefloquine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 7
- Contraindicated
- 2
- Major
- 3
- Moderate
- 2
Contraindicated (2)
- Mefloquine + Pimozide— Additive QT interval prolongation effect anticipated, increasing risk of ventricular arrhythmias.
- Mefloquine + Quinine Sulfate— Other antimalarial causing ECG abnormalities including QT prolongation when combined with quinine sulfate.
Major (3)
- Mefloquine + Chloroquine Phosphate— Co-administration of chloroquine and mefloquine may increase the risk of convulsions.
- Mefloquine + Hydroxychloroquine— Co-administration may increase the risk of seizures as both drugs lower seizure threshold.
- Mefloquine + Hydroxychloroquine Sulfate— Co-administration may increase the risk of convulsions as both drugs lower the convulsive threshold.
Moderate (2)
- Mefloquine + Artemether And Lumefantrine— When used immediately before artemether and lumefantrine, may decrease lumefantrine exposure and efficacy. Monitor effic…
- Mefloquine + Pyridostigmine Bromide— Additive effects on gastrointestinal tract (loose bowels) and atrial rate with concomitant use.