Mephenytoin has 2 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Fexinidazole, Osilodrostat. Patients taking Mephenytoin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 2
- Moderate
- 2
Moderate (2)
- Mephenytoin + Fexinidazole— Fexinidazole inhibits CYP2C19, increasing mephenytoin concentrations and risk of adverse reactions.
- Mephenytoin + Osilodrostat— CYP2C19 substrate with narrow therapeutic index. Use with caution as osilodrostat may affect S-mephenytoin metabolism.