Aminoglutethimide has 25 known drug interactions based on U.S. FDA drug labeling data. 9 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine, Conjugated Estrogens And Medroxyprogesterone Acetate, Depo-Medrol, Lidocaine, Isopropyl Alcohol. Patients taking Aminoglutethimide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 25
- Major
- 9
- Moderate
- 13
Major (9)
- Aminoglutethimide + Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine— Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression.
- Aminoglutethimide + Conjugated Estrogens And Medroxyprogesterone Acetate— Significantly depresses the bioavailability of medroxyprogesterone acetate when administered concomitantly.
- Aminoglutethimide + Depo-Medrol, Lidocaine, Isopropyl Alcohol— Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression.
- Aminoglutethimide + Hydrocortisone Sodium Succinate— Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression.
- Aminoglutethimide + Kenalog— Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression.
- Aminoglutethimide + Methylprednisolone— Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression.
- Aminoglutethimide + Methylprednisolone Acetate— Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression.
- Aminoglutethimide + Prednisolone Sodium Phosphate— Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression.
- Aminoglutethimide + Triamcinolone Acetonide— Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression.
Moderate (13)
- Aminoglutethimide + Dexamethasone— Aminoglutethimide may diminish adrenal suppression by dexamethasone.
- Aminoglutethimide + Dexamethasone 1.5 Mg— Aminoglutethimide may diminish adrenal suppression by dexamethasone.
- Aminoglutethimide + Dexamethasone Intensol— Aminoglutethimide may diminish adrenal suppression by dexamethasone.
- Aminoglutethimide + Hydrocortisone Acetate— Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression.
- Aminoglutethimide + Levothyroxine Sodium— May decrease thyroid hormone secretion and result in hypothyroidism; long-term therapy may minimally decrease T4 and T3 …
- Aminoglutethimide + Marcaine, Kenalog, Povidone Iodine— Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression with methylprednisolone acetate.
- Aminoglutethimide + Marcaine, Lidocaine, Kenalog, Povidone Iodine— Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression.
- Aminoglutethimide + Methylprednisolone Acetate, Lidocaine Hydrochloride, Povidine Iodine, Isopropyl Alcohol— Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression.
- Aminoglutethimide + Methylprednisolone Sodium Succinate— Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression.
- Aminoglutethimide + Prednisone— May lead to loss of corticosteroid-induced adrenal suppression.
- Aminoglutethimide + Tamoxifen Citrate— Reduces tamoxifen and N-desmethyl tamoxifen plasma concentrations.
- Aminoglutethimide + Theophylline— Aminoglutethimide increases theophylline clearance.
- Aminoglutethimide + Triamcinolone Acetonide Extended-Release Injectable Suspension— Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression.