Rocuronium has 20 known drug interactions based on U.S. FDA drug labeling data. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Bacitracin, Colistimethate Sodium, Colistin. Patients taking Rocuronium should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 20
- Major
- 8
- Moderate
- 5
- Minor
- 3
Major (8)
- Rocuronium + Bacitracin— May enhance neuromuscular blocking action of rocuronium, prolonging neuromuscular block.
- Rocuronium + Colistimethate Sodium— May enhance neuromuscular blocking action of rocuronium, prolonging neuromuscular block.
- Rocuronium + Colistin— May enhance neuromuscular blocking action of rocuronium, prolonging neuromuscular block.
- Rocuronium + Magnesium Sulfate Heptahydrate— Potentiation and prolongation of neuromuscular blockade is possible with concomitant use. Monitor respiration and depth …
- Rocuronium + Magnesium Sulfate In Dextrose— Potentiation and prolongation of neuromuscular blockade is possible. Magnesium suppresses peripheral neuromuscular funct…
- Rocuronium + Polymyxins— May enhance neuromuscular blocking action of rocuronium, prolonging neuromuscular block.
- Rocuronium + Tetracycline— May enhance neuromuscular blocking action of rocuronium, prolonging neuromuscular block.
- Rocuronium + Vancomycin— May enhance neuromuscular blocking action of rocuronium, prolonging neuromuscular block.
Moderate (5)
- Rocuronium + Carbamazepine— Chronic carbamazepine therapy may cause resistance to rocuronium effects, resulting in shorter neuromuscular block durat…
- Rocuronium + Enflurane— Enflurane enhances rocuronium activity, prolonging neuromuscular block duration and decreasing infusion requirements by …
- Rocuronium + Ephedrine Sulfate— Ephedrine may reduce the onset time of neuromuscular blockade when used simultaneously with anesthetic induction for int…
- Rocuronium + Isoflurane— Isoflurane enhances rocuronium activity, prolonging neuromuscular block duration and decreasing infusion requirements by…
- Rocuronium + Phenytoin— Chronic phenytoin therapy may cause resistance to rocuronium effects, resulting in shorter neuromuscular block duration …
Minor (3)
- Rocuronium + Dexmedetomidine— Administration of dexmedetomidine resulted in no clinically meaningful increases in neuromuscular blockade magnitude.
- Rocuronium + Dexmedetomidine Hydrochloride— Administration of dexmedetomidine hydrochloride at plasma concentration of 1 ng/mL resulted in no clinically meaningful …
- Rocuronium + Dexmedetomidine Hydrochloride In 0.9% Sodium Chloride— Administration of dexmedetomidine at 1 ng/mL plasma concentration resulted in no clinically meaningful increases in neur…