Pemetrexed has 6 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Sepiapterin, Diclofenac, Diclofenac Sodium And Menthol, Methyl Salicylate. Patients taking Pemetrexed should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Contraindicated
- 1
- Major
- 5
Contraindicated (1)
- Pemetrexed + Sepiapterin— DHFR inhibitor that may reduce sepiapterin metabolism to tetrahydrobiopterin (BH4). Avoid concomitant use.
Major (5)
- Pemetrexed + Diclofenac— Concomitant use may increase risk of pemetrexed-associated myelosuppression, renal, and GI toxicity.
- Pemetrexed + Diclofenac Sodium And Menthol, Methyl Salicylate— Concomitant use may increase risk of pemetrexed-associated myelosuppression, renal, and GI toxicity.
- Pemetrexed + Ibuprofen— Ibuprofen increases pemetrexed exposure (AUC) and increases risk of toxicity in patients with mild to moderate renal imp…
- Pemetrexed + Methotrexate— Antifolate drug that may increase methotrexate plasma concentrations, increasing risk of severe adverse reactions and po…
- Pemetrexed + Methotrexate Sodium— Antifolate drug that may increase methotrexate plasma concentrations, increasing risk of severe adverse reactions and po…