Pemetrexed + Ibuprofen Interaction
Majorinteraction on record
Description
Ibuprofen increases pemetrexed exposure (AUC) and increases risk of toxicity in patients with mild to moderate renal impairment (CrCl 45-79 mL/min). Avoid ibuprofen for 2 days before, day of, and 2 days after pemetrexed administration.
Mechanism
Ibuprofen increases pemetrexed AUC exposure
Source: NLP:pemetrexed