Aminophylline has 46 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Ketamine Hydrochloride, Adenosine, Arformoterol Tartrate. Patients taking Aminophylline should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 46
- Contraindicated
- 1
- Moderate
- 11
Contraindicated (1)
- Aminophylline + Ketamine Hydrochloride— Concomitant use may lower the seizure threshold. Do not co-administer with ketamine hydrochloride.
Moderate (11)
- Aminophylline + Adenosine— Theophylline blocks adenosine receptors, requiring higher doses of adenosine to achieve therapeutic effect.
- Aminophylline + Arformoterol Tartrate— Xanthine derivative may potentiate hypokalemia. Concomitant use may increase heart rate and systolic blood pressure. Use…
- Aminophylline + Carbamazepine— CYP3A4 inducer that decreases carbamazepine plasma levels. Carbamazepine levels and/or dosage adjustment may be necessar…
- Aminophylline + Cimetidine— Cimetidine inhibits theophylline clearance, resulting in increased serum theophylline concentrations requiring dose redu…
- Aminophylline + Doxapram Hydrochloride— Interaction may manifest as increased skeletal muscle activity, agitation, and hyperactivity when combined with doxapram…
- Aminophylline + Erythromycin— Erythromycin inhibits theophylline clearance, resulting in increased serum theophylline concentrations requiring dose re…
- Aminophylline + Lorazepam— May reduce the sedative effects of lorazepam.
- Aminophylline + Quinine— No change in quinine dosage necessary with concomitant use. Patients should be monitored closely for adverse reactions a…
- Aminophylline + Quinine Sulfate— No change in quinine dosage necessary with concomitant use. Patients should be monitored closely for adverse reactions a…
- Aminophylline + Regadenoson— Methylxanthine that interferes with the vasodilation activity of regadenoson. Patients should avoid for at least 12 hour…
- Aminophylline + Rifampin— Rifampin enhances theophylline clearance, resulting in decreased serum theophylline concentrations requiring dose increa…