Metolazone has 17 known drug interactions based on U.S. FDA drug labeling data. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Digitalis Glycosides, Furosemide, Lithium. Patients taking Metolazone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 17
- Major
- 5
- Moderate
- 12
Major (5)
- Metolazone + Digitalis Glycosides— Diuretic-induced hypokalemia can increase myocardial sensitivity to digitalis, resulting in serious arrhythmias.
- Metolazone + Furosemide— Concomitant use can cause unusually large or prolonged losses of fluid and electrolytes.
- Metolazone + Lithium— Serum lithium levels may increase, potentially leading to lithium toxicity.
- Metolazone + Loop Diuretics— Concomitant use can cause unusually large or prolonged losses of fluid and electrolytes.
- Metolazone + Tubocurarine— Diuretic-induced hypokalemia may enhance neuromuscular blocking effects, potentially causing respiratory depression or a…
Moderate (12)
- Metolazone + Acidifying Agents— Metolazone may affect glucose tolerance; dosage adjustments may be necessary.
- Metolazone + Alcohol— Hypotensive effects may be potentiated by volume contraction associated with metolazone therapy.
- Metolazone + Barbiturates— Hypotensive effects may be potentiated by volume contraction associated with metolazone therapy.
- Metolazone + Corticosteroids— May increase risk of hypokalemia and increase salt and water retention.
- Metolazone + Insulin Human— May affect glucose tolerance; dosage adjustments of insulin may be necessary.
- Metolazone + Methenamine Salts— Efficacy may be decreased due to urinary alkalizing effect of metolazone.
- Metolazone + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)— May decrease the antihypertensive effects of metolazone.
- Metolazone + Norepinephrine— Metolazone may decrease arterial responsiveness to norepinephrine, though not sufficient to preclude therapeutic effecti…
- Metolazone + Oral Anticoagulants— Metolazone may affect hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary.
- Metolazone + Other Anticholinergic Agents— Care must be taken during initial therapy; dosage adjustments of other antihypertensives may be necessary.
- Metolazone + Repository Corticotropin— May increase risk of hypokalemia and increase salt and water retention.
- Metolazone + Salicylates— May decrease the antihypertensive effects of metolazone.