Metyrapone Interactions

Brand names: Metopirone

Adrenal Steroid Synthesis Inhibitor · Adrenal Steroid Synthesis Inhibitors

Route: Oral

Contraindications

4 CONTRAINDICATIONS Metopirone is contraindicated in patients with adrenal cortical insufficiency or hypersensitivity to Metopirone or to any of its excipients. In patients with adrenal cortical insufficiency ( 4 ) Hypersensitivity to Metopirone or to any of its excipients ( 4 )

Pregnancy & Breastfeeding

8.1 Pregnancy Risk Summary Available data from published case series and reports on Metopirone use in pregnant females are insufficient to identify a drug-associated risk of major birth defects or miscarriage. Metyrapone crosses the placenta and may decrease fetal cortisol production (see Data ) . Animal reproductive studies have not been conducted with metyrapone. Metyrapone can decrease reproductive hormones by targeting adrenal androgenesis. Data Human Data The Metopirone test was administered to pregnant women in their second and third trimester of pregnancy and evidence was found that the fetal pituitary responded to the enzymatic block. Transplacental transfer of Metopirone has been shown in humans and the drug can impair the biosynthesis of fetal and placental steroids. There are a few published reports of low cortisol levels at birth in infants exposed in utero following chronic use of metyrapone in pregnant females.

6 interactions on record

Metyrapone + AcetaminophenMajor

Metyrapone inhibits glucuronidation of acetaminophen, decreasing elimination and increasing risk of adverse reactions. Avoid concomitant use.

Source: NLP:metyrapone

Metyrapone + Acidifying AgentsModerate