Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin.
Source: FDA drug label - minocycline hydrochloride
Minocycline Hydrochloride Interactions
Brand names: Minocycline Hydrochloride
3 interactions on record
Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin. Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations.
Source: FDA drug label - minocycline hydrochloride
Administration of isotretinoin should be avoided shortly before, during, and shortly after minocycline therapy.
Source: FDA drug label - minocycline hydrochloride