Minocycline Hydrochloride has 18 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Isotretinoin, Methoxyflurane, Adrenergic Blockers. Patients taking Minocycline Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 18
- Contraindicated
- 2
- Major
- 7
- Moderate
- 9
Contraindicated (2)
- Minocycline Hydrochloride + Isotretinoin— Administration of isotretinoin should be avoided shortly before, during, and shortly after minocycline therapy; both ass…
- Minocycline Hydrochloride + Methoxyflurane— Concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity.
Major (7)
- Minocycline Hydrochloride + Adrenergic Blockers— Potentially serious drug interactions may occur when intravenous magnesium sulfate is given concomitantly with neuromusc…
- Minocycline Hydrochloride + Cardiac Glycosides— Potentially serious drug interactions may occur when intravenous magnesium sulfate is given concomitantly with cardiac g…
- Minocycline Hydrochloride + Cns Depressants— Potentially serious drug interactions may occur when intravenous magnesium sulfate is given concomitantly with CNS depre…
- Minocycline Hydrochloride + Ergot Alkaloids— Increased risk of ergotism when ergot alkaloids are given with tetracyclines.
- Minocycline Hydrochloride + Minocycline— 7.2 Penicillin Because bacteriostatic drugs may interfere with the bactericidal action of penicillin, avoid giving minoc…
- Minocycline Hydrochloride + Penicillin— Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tet…
- Minocycline Hydrochloride + Tetracycline— Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anti…
Moderate (9)
- Minocycline Hydrochloride + Antacids Containing Aluminum— Antacids containing aluminum impair absorption of tetracyclines.
- Minocycline Hydrochloride + Antacids Containing Calcium— Antacids containing calcium impair absorption of tetracyclines.
- Minocycline Hydrochloride + Antacids Containing Calcium, Magnesium, Or Aluminum— Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium.
- Minocycline Hydrochloride + Antacids Containing Magnesium— Antacids containing magnesium impair absorption of tetracyclines.
- Minocycline Hydrochloride + Calcium Antagonists— Absorption of tetracyclines is impaired by antacids containing calcium; may reduce minocycline effectiveness.
- Minocycline Hydrochloride + Iron-Containing Preparations— Iron-containing preparations impair absorption of tetracyclines.
- Minocycline Hydrochloride + Oral Anticoagulants— Tetracyclines depress plasma prothrombin activity; patients may require downward adjustment of anticoagulant dosage.
- Minocycline Hydrochloride + Oral Contraceptives— Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective.
- Minocycline Hydrochloride + Steroid Therapy— Tetracyclines depress plasma prothrombin activity; patients may require downward adjustment of anticoagulant dosage.