3 interactions on record
Since both oral retinoids, including isotretinoin and acitretin, and the tetracyclines, primarily minocycline, can cause increased intracranial pressure, the concurrent use of an oral retinoid and a tetracycline should be avoided.
Source: FDA drug label - doxycycline
However, there has been evidence of oncogenic activity in rats in studies with the related antibacterial drugs, oxytetracycline (adrenal and pituitary tumors), and minocycline (thyroid tumors).
Source: FDA drug label - doxycycline hyclate
Administration of isotretinoin should be avoided shortly before, during, and shortly after minocycline therapy.
Source: FDA drug label - minocycline hydrochloride