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Minocycline

Route: Topical

6 interactions on record

Minocycline has 6 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Minocycline Hydrochloride, Penicillin, Tetracycline. Patients taking Minocycline should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 6
Major: 3
Moderate: 1

Major (3)

Minocycline + Minocycline Hydrochloride— 7.2 Penicillin Because bacteriostatic drugs may interfere with the bactericidal action of penicillin, avoid giving minoc…
Minocycline + Penicillin— ( 7.1 ) • Penicillin: avoid coadministration. 7.2 Penicillin Since bacteriostatic drugs may interfere with the bacterici…
Minocycline + Tetracycline— ( 7.2 ) 7.1 Anticoagulants Because tetracyclines have been shown to depress plasma prothrombin activity, patients who ar…

Moderate (1)

Minocycline + Oral Anticoagulants— Tetracyclines depress plasma prothrombin activity; patients may require downward adjustment of anticoagulant dosage.

Minocycline + Minocycline Hydrochloride⚠️Major

7.2 Penicillin Because bacteriostatic drugs may interfere with the bactericidal action of penicillin, avoid giving minocycline hydrochloride in conjunction with penicillin.

Minocycline + Penicillin⚠️Major

( 7.1 ) • Penicillin: avoid coadministration. 7.2 Penicillin Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin.

Minocycline + Tetracycline⚠️Major

( 7.2 ) 7.1 Anticoagulants Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. 7.2 Penicillin Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin.

Minocycline + Oral Anticoagulants🟡Moderate

Tetracyclines depress plasma prothrombin activity; patients may require downward adjustment of anticoagulant dosage.

Minocycline + Doxycyclineℹ️Unknown

Since both oral retinoids, including isotretinoin and acitretin, and the tetracyclines, primarily minocycline, can cause increased intracranial pressure, the concurrent use of an oral retinoid and a tetracycline should be avoided.

Minocycline + Doxycycline Hyclateℹ️Unknown

However, there has been evidence of oncogenic activity in rats in studies with the related antibacterial drugs, oxytetracycline (adrenal and pituitary tumors), and minocycline (thyroid tumors).

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.