Sotalol Hydrochloride has 21 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amiodarone, Disopyramide, Procainamide. Patients taking Sotalol Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 21
- Contraindicated
- 4
- Major
- 8
- Moderate
- 8
Contraindicated (4)
- Sotalol Hydrochloride + Amiodarone— Class III antiarrhythmic; potential to prolong refractoriness. Not recommended as concomitant therapy with sotalol.
- Sotalol Hydrochloride + Disopyramide— Class Ia antiarrhythmic; potential to prolong refractoriness. Discontinue for at least three half-lives prior to sotalol…
- Sotalol Hydrochloride + Procainamide— Class Ia antiarrhythmic; potential to prolong refractoriness. Discontinue for at least three half-lives prior to sotalol…
- Sotalol Hydrochloride + Quinidine— Class Ia antiarrhythmic; potential to prolong refractoriness. Discontinue for at least three half-lives prior to sotalol…
Major (8)
- Sotalol Hydrochloride + Calcium Channel Blockers— Additive effects on atrioventricular conduction and ventricular function. Monitor for bradycardia and hypotension.
- Sotalol Hydrochloride + Clonidine— Concomitant use increases risk of bradycardia and rebound hypertension upon discontinuation. Withdraw sotalol several da…
- Sotalol Hydrochloride + Digoxin— Digitalis glycoside; concomitant use increases risk of bradycardia and hypotension.
- Sotalol Hydrochloride + Diltiazem— Calcium channel blocker; concomitant use increases risk of bradycardia and hypotension.
- Sotalol Hydrochloride + Guanethidine— Catecholamine-depleting agent; may produce excessive reduction of resting sympathetic nervous tone, causing hypotension …
- Sotalol Hydrochloride + Quinolone— 7 DRUG INTERACTIONS Class I or III Antiarrhythmics or other drugs that prolong the QT interval: Avoid concomitant use ( …
- Sotalol Hydrochloride + Reserpine— Catecholamine-depleting agent; may produce excessive reduction of resting sympathetic nervous tone, causing hypotension …
- Sotalol Hydrochloride + Verapamil— Calcium channel blocker; concomitant use increases risk of bradycardia and hypotension.
Moderate (8)
- Sotalol Hydrochloride + Albuterol— Beta-agonist; may require increased dosages when used concomitantly with sotalol.
- Sotalol Hydrochloride + Aluminum Oxide— Reduces sotalol exposure; avoid administration of oral sotalol within 2 hours of antacids containing aluminum oxide.
- Sotalol Hydrochloride + Calcium Antagonists— Possible additive effects on atrioventricular conduction, ventricular function, and blood pressure, potentially leading …
- Sotalol Hydrochloride + Digitalis Glycosides— Both slow atrioventricular conduction and decrease heart rate; concomitant use increases risk of bradycardia.
- Sotalol Hydrochloride + Insulin Human— Dosage may require adjustment due to potential hyperglycemia when used concomitantly with sotalol.
- Sotalol Hydrochloride + Isoproterenol— Beta-agonist; may require increased dosages when used concomitantly with sotalol.
- Sotalol Hydrochloride + Magnesium Hydroxide— Reduces sotalol exposure; avoid administration of oral sotalol within 2 hours of antacids containing magnesium hydroxide…
- Sotalol Hydrochloride + Terbutaline— Beta-agonist; may require increased dosages when used concomitantly with sotalol.