Palonosetron has 2 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Apomorphine Hydrochloride, Selective Serotonin Reuptake Inhibitors (Ssri). Patients taking Palonosetron should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 2
- Contraindicated
- 1
- Major
- 1
Contraindicated (1)
- Palonosetron + Apomorphine Hydrochloride— Concomitant use with apomorphine hydrochloride is contraindicated due to reports of profound hypotension and loss of con…
Major (1)
- Palonosetron + Selective Serotonin Reuptake Inhibitors (Ssri)— Concomitant use may cause serotonin syndrome including altered mental status, autonomic instability, and neuromuscular s…