Muscle Relaxants has 36 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 21 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Hydrocodone Bitartrate And Homatropine Methylbromide, Hydrocodone Polistirex And Chlorpheniramine Polistirex, Buprenorphine. Patients taking Muscle Relaxants should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 36
- Contraindicated
- 2
- Major
- 21
- Moderate
- 11
- Minor
- 1
Contraindicated (2)
- Muscle Relaxants + Hydrocodone Bitartrate And Homatropine Methylbromide— Avoid concomitant use with hydrocodone bitartrate and homatropine methylbromide.
- Muscle Relaxants + Hydrocodone Polistirex And Chlorpheniramine Polistirex— Avoid concomitant use.
Major (21)
- Muscle Relaxants + Buprenorphine— CNS depressants that increase risk of respiratory depression, profound sedation, coma, and death with concomitant bupren…
- Muscle Relaxants + Buprenorphine And Naloxone— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
- Muscle Relaxants + Buprenorphine Hydrochloride— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
- Muscle Relaxants + Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
- Muscle Relaxants + Butorphanol Tartrate— CNS depressant effects increase risk of respiratory depression, profound sedation, coma, and death.
- Muscle Relaxants + Codeine Phosphate And Chlorpheniramine Maleate— Avoid concomitant use with codeine.
- Muscle Relaxants + Cyclophosphamide— Cyclophosphamide causes marked and persistent inhibition of cholinesterase activity, which may result in prolonged apnea…
- Muscle Relaxants + Dantrolene Sodium— Concomitant use may potentiate neuromuscular block and muscle relaxant effects.
- Muscle Relaxants + Hydrocodone Bitartrate And Acetaminophen— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death; reserve for patients where…
- Muscle Relaxants + Hydrocodone Bitartrate And Homatropine Methylbromide Oral Solution— Avoid concomitant use with hydrocodone bitartrate and homatropine methylbromide.
- Muscle Relaxants + Hydromorphone Hydrochloride— Hydromorphone may enhance neuromuscular blocking action and produce increased respiratory depression.
- Muscle Relaxants + Levorphanol Tartrate— Enhanced neuromuscular blocking action and increased respiratory depression.
- Muscle Relaxants + Methadone Hydrochloride— CNS depressant effect increases risk of respiratory depression, profound sedation, coma, and death.
- Muscle Relaxants + Morphine Sulfate— Morphine may enhance neuromuscular blocking action and produce increased degree of respiratory depression.
- Muscle Relaxants + Nalbuphine Hydrochloride— Nalbuphine may enhance neuromuscular blocking action and produce increased respiratory depression. Monitor for respirato…
- Muscle Relaxants + Pentazocine Hydrochloride And Naloxone Hydrochloride— Concomitant use may enhance neuromuscular blocking action and produce increased respiratory depression. Monitor for sign…
- Muscle Relaxants + Promethazine Hydrochloride And Codeine Phosphate— Avoid concomitant use due to potential adverse effects.
- Muscle Relaxants + Promethazine, Phenylephrine, Codeine— Avoid concomitant use with this combination product.
- Muscle Relaxants + Remifentanil Hydrochloride— CNS depressants increase risk of hypotension, respiratory depression, profound sedation, coma, and death.
- Muscle Relaxants + Scolopamine Transdermal System— Concurrent use may potentiate CNS adverse reactions including drowsiness, dizziness, and disorientation.
- Muscle Relaxants + Scopolamine— Concurrent use may potentiate CNS adverse reactions and increase risk of intestinal obstruction and urinary retention. M…
Moderate (11)
- Muscle Relaxants + Acetaminophen, Caffeine, Dihydrocodeine Bitartrate— Additive CNS depressant effects when combined with dihydrocodeine; dose reduction of one or both agents recommended.
- Muscle Relaxants + Botulinum Toxin Type A— May potentiate JEUVEAU's effects. Close observation recommended during concomitant use.
- Muscle Relaxants + Diphenoxylate Hydrochloride And Atropine Sulfate— May potentiate CNS depressant effects of diphenoxylate hydrochloride and atropine sulfate. Monitor for CNS adverse react…
- Muscle Relaxants + Incobotulinumtoxina— Muscle relaxants administered before or after incobotulinumtoxina may exaggerate excessive weakness.
- Muscle Relaxants + Isoflurane— Isoflurane potentiates the muscle relaxant effect of all muscle relaxants, most notably nondepolarizing muscle relaxants…
- Muscle Relaxants + Letibotulinumtoxina-Wlbg— Muscle relaxants administered before or after LETYBO may potentiate excessive neuromuscular weakness. Use caution and mo…
- Muscle Relaxants + Nabilone— Additive drowsiness and CNS depression reported with concurrent use.
- Muscle Relaxants + Onabotulinumtoxina— Administration before or after BOTOX may exaggerate excessive weakness. Close observation recommended.
- Muscle Relaxants + Rimabotulinumtoxinb— Administration before or after rimabotulinumtoxinb may exaggerate excessive weakness.
- Muscle Relaxants + Triamterene— Effects of non-depolarizing skeletal muscle relaxants may be potentiated when given with triamterene.
- Muscle Relaxants + Triamterene Capsules— Non-depolarizing skeletal muscle relaxants effects may be potentiated when given together with triamterene.
Minor (1)
- Muscle Relaxants + Propofol— Propofol does not cause clinically significant changes in onset, intensity, or duration of action.