Raltegravir has 34 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Rilpivirine, Rifampin, Antacids Containing Calcium. Patients taking Raltegravir should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 34
- Contraindicated
- 1
- Major
- 1
- Moderate
- 7
Contraindicated (1)
- Raltegravir + Rilpivirine— Proton Pump Inhibitors: e.g., esomeprazole lansoprazole omeprazole pantoprazole rabeprazole ↓ rilpivirine Coadministrati…
Major (1)
- Raltegravir + Rifampin— Strong inducer of UGT1A1 that reduces plasma concentrations of raltegravir. Dose adjustment to 800 mg twice daily recomm…
Moderate (7)
- Raltegravir + Antacids Containing Calcium— Decreases raltegravir plasma concentrations. Coadministration not recommended despite no dose adjustment needed for ISEN…
- Raltegravir + Antacids Containing Magnesium— Decreases raltegravir plasma concentrations. Coadministration or staggered administration not recommended.
- Raltegravir + Carbamazepine— Strong inducer of drug metabolizing enzymes that may decrease raltegravir levels. Coadministration not recommended.
- Raltegravir + Etravirine— Decreases raltegravir plasma concentrations. No dose adjustment needed but coadministration not recommended for ISENTRES…
- Raltegravir + Phenobarbital— Strong inducer of drug metabolizing enzymes that may decrease raltegravir levels. Coadministration not recommended.
- Raltegravir + Phenytoin— Strong inducer of drug metabolizing enzymes that may decrease raltegravir levels. Coadministration not recommended.
- Raltegravir + Tipranavir— No dose adjustment required for ISENTRESS, but coadministration not recommended for ISENTRESS HD.