Silodosin has 11 known drug interactions based on U.S. FDA drug labeling data. Of these, 5 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alpha-Blockers, Cyclosporine, Itraconazole. Patients taking Silodosin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 11
- Contraindicated
- 5
- Major
- 2
- Moderate
- 3
- Minor
- 1
Contraindicated (5)
- Silodosin + Alpha-Blockers— Pharmacodynamic interactions may be expected. Silodosin should not be used in combination with other alpha-blockers.
- Silodosin + Cyclosporine— Strong P-glycoprotein inhibitor that may increase plasma silodosin concentration. Concomitant use is not recommended.
- Silodosin + Itraconazole— Strong CYP3A4 inhibitor that may cause significant increase in silodosin plasma concentrations. Concomitant administrati…
- Silodosin + Ketoconazole— Strong CYP3A4 inhibitor causing 3.8-fold increase in silodosin maximum plasma concentrations and 3.2-fold increase in ex…
- Silodosin + Ritonavir— Strong CYP3A4 inhibitor that may cause significant increase in silodosin plasma concentrations. Concomitant administrati…
Major (2)
- Silodosin + Sildenafil— PDE5 inhibitor that with silodosin can cause symptomatic hypotension with increased positive orthostatic test results.
- Silodosin + Tadalafil— PDE5 inhibitor that with silodosin can cause symptomatic hypotension with increased positive orthostatic test results.
Moderate (3)
- Silodosin + Diltiazem— Moderate CYP3A4 inhibitor that may increase silodosin concentration. Monitor patients for adverse events.
- Silodosin + Erythromycin— Concomitant administration with moderate CYP3A4 inhibitors (e.g., diltiazem, erythromycin, verapamil) may increase conce…
- Silodosin + Verapamil— Moderate CYP3A4 inhibitor that may increase silodosin concentration. Monitor patients for adverse events.
Minor (1)
- Silodosin + Digoxin— Concomitant administration did not significantly alter the steady state pharmacokinetics of digoxin. No dose adjustment …