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Raloxifene

Also known as: Raloxifene Hydrochloride

Route: Oral

9 interactions on record⛔ Black Box Warning

Raloxifene has 9 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cholestyramine Light, Estrogens, Diazepam. Patients taking Raloxifene should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 9
Major: 2
Moderate: 5

Major (2)

Raloxifene + Cholestyramine Light— Reduces the absorption and enterohepatic cycling of raloxifene. Use with raloxifene hydrochloride tablets is not recomme…
Raloxifene + Estrogens— Safety of concomitant use has not been established and use is not recommended.

Moderate (5)

Raloxifene + Diazepam— Highly protein-bound drugs include diazepam, diazoxide, and lidocaine. 7.3 Other Highly Protein-Bound Drugs Raloxifene h…
Raloxifene + Diazoxide— Use with caution; raloxifene is highly protein-bound and may affect protein binding of diazoxide.
Raloxifene + Famciclovir— Potent aldehyde oxidase inhibitor that could decrease the formation of penciclovir, though clinical interaction magnitud…
Raloxifene + Lidocaine— Use with caution; raloxifene is highly protein-bound and may affect protein binding of lidocaine.
Raloxifene + Warfarin— Monitor prothrombin time when starting or stopping raloxifene; may affect warfarin efficacy.

Raloxifene + Cholestyramine Light⚠️Major

Reduces the absorption and enterohepatic cycling of raloxifene. Use with raloxifene hydrochloride tablets is not recommended.

Raloxifene + Estrogens⚠️Major

Safety of concomitant use has not been established and use is not recommended.

Raloxifene + Diazepam🟡Moderate

Highly protein-bound drugs include diazepam, diazoxide, and lidocaine. 7.3 Other Highly Protein-Bound Drugs Raloxifene hydrochloride tablets should be used with caution with certain other highly protein-bound drugs such as diazepam, diazoxide, and lidocaine.

Raloxifene + Diazoxide🟡Moderate

Use with caution; raloxifene is highly protein-bound and may affect protein binding of diazoxide.

Raloxifene + Famciclovir🟡Moderate

Potent aldehyde oxidase inhibitor that could decrease the formation of penciclovir, though clinical interaction magnitude is unknown.

Raloxifene + Lidocaine🟡Moderate

Use with caution; raloxifene is highly protein-bound and may affect protein binding of lidocaine.

Raloxifene + Warfarin🟡Moderate

Monitor prothrombin time when starting or stopping raloxifene; may affect warfarin efficacy.

Raloxifene + Amoxicillinℹ️Unknown

7.5 Other Concomitant Medications Raloxifene hydrochloride tablets can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology (12.3) ].

Raloxifene + Ampicillinℹ️Unknown

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.