Fosphenytoin Interactions

Carboplatin decreases fosphenytoin serum levels, which may lead to exacerbation of seizures.

Source: NLP:carboplatin

Enzyme-inducing anti-epileptic drug that decreases imatinib AUC by 73%, significantly reducing imatinib exposure.

Source: NLP:imatinib

CYP3A4 inducer that decreases carbamazepine plasma levels. Carbamazepine levels and/or dosage adjustment may be necessary.

Source: NLP:carbamazepine

High doses of folic acid may decrease serum levels of this anticonvulsant drug.

Source: NLP:doconexent, niacinamide, .alpha.-tocopherol acetate, dl-, cholecalciferol, beta carotene, ascorbic acid, thiamine mononitrate, riboflavin, pyridoxine hydrochloride, cyanocobalamin, iron, zinc oxide, cupric oxide, potassium iodide, magnesium oxide, folic acid, and levomefolate calcium

Impairs folate absorption and increases metabolism of circulating folate.

Source: NLP:prenatal multivitamin tablet and combination omega-3 softgel/mineral capsule

Concomitant administration may affect fosphenytoin pharmacokinetics. Adjustment of anticonvulsant and/or tinidazole doses may be needed.

Source: NLP:tinidazole