Nadolol has 12 known drug interactions based on U.S. FDA drug labeling data. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Digitalis Glycosides, Epinephrine, Reserpine. Patients taking Nadolol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 12
- Major
- 4
- Moderate
- 3
Major (4)
- Nadolol + Digitalis Glycosides— Both digitalis glycosides and nadolol slow atrioventricular conduction and decrease heart rate; concomitant use increase…
- Nadolol + Epinephrine— Patients taking nadolol with history of severe anaphylactic reactions may be unresponsive to usual doses of epinephrine …
- Nadolol + Reserpine— Additive effect with nadolol; monitor closely for hypotension and/or excessive bradycardia (vertigo, syncope, postural h…
- Nadolol + Topical Local Anesthetics— Exaggeration of hypotension induced by general anesthetics when administered concurrently with nadolol.
Moderate (3)
- Nadolol + Acidifying Agents— Nadolol may cause hypoglycemia or hyperglycemia; adjust dosage of antidiabetic drug accordingly.
- Nadolol + Insulin Human— Nadolol may cause hypoglycemia or hyperglycemia; adjust dosage of insulin accordingly.
- Nadolol + Itraconazole— Beta Blockers Nadolol a Monitor for adverse reactions.