Nalbuphine has 9 known drug interactions based on U.S. FDA drug labeling data. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Atropa Belladonna And Opium, Hydrocodone Bitartrate And Acetaminophen, Hydromorphone Hydrochloride. Patients taking Nalbuphine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 9
- Major
- 6
- Moderate
- 3
Major (6)
- Nalbuphine + Atropa Belladonna And Opium— Mixed agonist/antagonist opioid may reduce analgesic effect and/or precipitate withdrawal symptoms. Avoid concomitant us…
- Nalbuphine + Hydrocodone Bitartrate And Acetaminophen— Mixed agonist/antagonist analgesic may precipitate withdrawal in opioid-dependent patients.
- Nalbuphine + Hydromorphone Hydrochloride— May reduce analgesic effect of hydromorphone and/or precipitate withdrawal symptoms. Avoid concomitant use.
- Nalbuphine + Levorphanol Tartrate— Mixed agonist/antagonist opioid may reduce analgesic effect of levorphanol and precipitate withdrawal symptoms. Advise p…
- Nalbuphine + Morphine Sulfate— Mixed agonist/antagonist opioid may reduce analgesic effect of morphine and/or precipitate withdrawal symptoms; avoid co…
- Nalbuphine + Pentazocine Hydrochloride And Naloxone Hydrochloride— Mixed agonist/antagonist opioid may reduce analgesic effect and precipitate withdrawal symptoms. Avoid concomitant use.
Moderate (3)
- Nalbuphine + Acetaminophen, Caffeine, Dihydrocodeine Bitartrate— Mixed agonist/antagonist opioid may reduce the analgesic effect of this combination product.
- Nalbuphine + Oxycodone Hydrochloride— Mixed agonist/antagonist may reduce analgesic effect and/or precipitate withdrawal symptoms in opioid-dependent patients…
- Nalbuphine + Remifentanil Hydrochloride— Mixed agonist/antagonist may reduce analgesic effect of remifentanil and/or precipitate withdrawal symptoms.