Alprazolam C-Iv has 28 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. 17 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Clarithromycin, Itraconazole, Ketoconazole. Patients taking Alprazolam C-Iv should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 28
- Contraindicated
- 4
- Major
- 17
- Moderate
- 7
Contraindicated (4)
- Alprazolam C-Iv + Clarithromycin— Concomitant use with strong CYP3A inhibitor is contraindicated due to profound effect on alprazolam clearance resulting …
- Alprazolam C-Iv + Itraconazole— Concomitant use with strong CYP3A inhibitor is contraindicated due to profound effect on alprazolam clearance resulting …
- Alprazolam C-Iv + Ketoconazole— Concomitant use with strong CYP3A inhibitor is contraindicated due to profound effect on alprazolam clearance resulting …
- Alprazolam C-Iv + Ritonavir— Strong Inhibitors of CYP3A (except ritonavir) Clinical implication Concomitant use of alprazolam with strong CYP3A inhib…
Major (17)
- Alprazolam C-Iv + Alfentanil— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Alprazolam C-Iv + Buprenorphine— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Alprazolam C-Iv + Butorpenol— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Alprazolam C-Iv + Codeine— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Alprazolam C-Iv + Dihydrocodeine— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Alprazolam C-Iv + Fentanyl— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Alprazolam C-Iv + Hydromorphone— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Alprazolam C-Iv + Meperidine— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Alprazolam C-Iv + Methadone— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Alprazolam C-Iv + Morphine— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Alprazolam C-Iv + Oxycodone— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Alprazolam C-Iv + Oxymorphone— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Alprazolam C-Iv + Pentazocine— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Alprazolam C-Iv + Remifentanil— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Alprazolam C-Iv + Sufentanil— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Alprazolam C-Iv + Tapentadol— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Alprazolam C-Iv + Tramadol— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
Moderate (7)
- Alprazolam C-Iv + Alprazolam— 7.1 Drugs Having Clinically Important Interactions with Alprazolam Table 4 includes clinically significant drug interact…
- Alprazolam C-Iv + Carbamazepine— CYP3A inducer can increase alprazolam metabolism and decrease plasma levels. Caution is recommended during coadministrat…
- Alprazolam C-Iv + Cimetidine— Weak CYP3A inhibitor may increase alprazolam concentrations. Avoid use and consider dose reduction.
- Alprazolam C-Iv + Erythromycin— Weak CYP3A inhibitor may increase alprazolam concentrations. Avoid use and consider dose reduction.
- Alprazolam C-Iv + Fluvoxamine— Weak CYP3A inhibitor may increase alprazolam concentrations. Avoid use and consider dose reduction.
- Alprazolam C-Iv + Nefazodone— Moderate CYP3A inhibitor may increase alprazolam concentrations. Avoid use and consider dose reduction.
- Alprazolam C-Iv + Phenytoin— CYP3A inducer can increase alprazolam metabolism and decrease plasma levels. Caution is recommended during coadministrat…