Naproxen has 27 known drug interactions based on U.S. FDA drug labeling data. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acidifying Agents, Aspirin, Benazepril Hydrochloride And Hydrochlorothiazide. Patients taking Naproxen should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 27
- Major
- 7
- Moderate
- 17
- Minor
- 1
Major (7)
- Naproxen + Acidifying Agents— Naproxen increases bleeding risk when used with antiplatelet agents. Monitor for signs of bleeding.
- Naproxen + Aspirin— Naproxen interferes with antiplatelet effect of aspirin and increases risk of GI adverse reactions and bleeding when use…
- Naproxen + Benazepril Hydrochloride And Hydrochlorothiazide— NSAID that may result in deterioration of renal function and attenuate antihypertensive effects.
- Naproxen + Lithium— NSAIDs can elevate plasma lithium levels and reduce renal lithium clearance, increasing risk of lithium toxicity. Monito…
- Naproxen + Methotrexate— NSAIDs may reduce tubular secretion of methotrexate and enhance its toxicity. Caution advised with concomitant use.
- Naproxen + Selective Serotonin Reuptake Inhibitors (Ssri)— SSRIs with naproxen potentiate risk of bleeding more than NSAID alone due to interference with serotonin reuptake and pl…
- Naproxen + Warfarin— Naproxen and warfarin have synergistic effect on bleeding with increased risk of serious bleeding compared to either dru…
Moderate (17)
- Naproxen + Aluminum Hydroxide— Concomitant administration can delay the absorption of naproxen.
- Naproxen + Angiotensin Ii— NSAIDs may diminish the antihypertensive effect of angiotensin receptor blockers.
- Naproxen + Cholestyramine Light— Concomitant administration can delay the absorption of naproxen.
- Naproxen + Cyclosporine— NSAID that may potentiate renal dysfunction with cyclosporine, particularly in dehydration. Close monitoring required.
- Naproxen + Furosemide— Naproxen can reduce the natriuretic effect of furosemide. Monitor closely for signs of renal failure and diuretic effica…
- Naproxen + Lithium Carbonate— NSAID decreases renal blood flow, resulting in decreased renal clearance and increased serum lithium concentrations.
- Naproxen + Magnesium Oxide— Concomitant administration can delay the absorption of naproxen.
- Naproxen + Mao Inhibitors— NSAIDs may diminish the antihypertensive effect of ACE inhibitors.
- Naproxen + Nonselective Beta-Adrenergic Antagonists— NSAIDs may diminish the antihypertensive effect of beta-blockers.
- Naproxen + Prenatal Multivitamin Tablet And Combination Omega-3 Softgel/Mineral Capsule— NSAIDs inhibit folate-dependent enzymes in laboratory experiments.
- Naproxen + Probenecid— Probenecid increases plasma elimination half-life and concentrations of naproxen; lower dosage may be required.
- Naproxen + Probenecid And Colchicine— Probenecid increases mean plasma elimination half-life and plasma concentrations of naproxen; use lower dosages cautious…
- Naproxen + Propranolol— Naproxen may diminish the antihypertensive effect of beta-blockers including propranolol.
- Naproxen + Salsalate— Salicylate competes with naproxen for protein binding sites, potentially affecting drug levels.
- Naproxen + Sucralfate— Concomitant administration can delay the absorption of naproxen.
- Naproxen + Sulopenem Etzadroxil And Probenecid— Probenecid inhibits OAT1/3, increasing naproxen plasma concentrations and risk of adverse reactions. May require dosage …
- Naproxen + Thiazides— Naproxen can reduce the natriuretic effect of thiazide diuretics. Monitor closely for signs of renal failure.
Minor (1)
- Naproxen + Gabapentin— Coadministration of naproxen and gabapentin increased gabapentin absorption by 12% to 15%. Gabapentin had no effect on n…