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Fluvastatin Sodium

Also known as: Fluvastatin Sodium

Route: Oral

10 interactions on record

Fluvastatin Sodium has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cyclosporine, Fluconazole, Gemfibrozil. Patients taking Fluvastatin Sodium should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 10
Contraindicated: 3
Major: 4
Moderate: 3

Contraindicated (3)

Fluvastatin Sodium + Cyclosporine— Cyclosporine increases fluvastatin exposure, increasing risk of myopathy and rhabdomyolysis. Avoid concomitant use.
Fluvastatin Sodium + Fluconazole— Fluconazole increases fluvastatin exposure, increasing risk of myopathy and rhabdomyolysis. Avoid concomitant use.
Fluvastatin Sodium + Gemfibrozil— Increased risk of myopathy and rhabdomyolysis when used concomitantly with fluvastatin. Avoid concomitant use.

Major (4)

Fluvastatin Sodium + Colchicine— May increase risk of myopathy and rhabdomyolysis with concomitant use. Consider if benefit outweighs risk and monitor fo…
Fluvastatin Sodium + Fibrates— Fibrates may cause myopathy when used alone; concomitant use with fluvastatin increases risk of myopathy and rhabdomyoly…
Fluvastatin Sodium + Fluvastatin— 7 DRUG INTERACTIONS • Gemfibrozil : Avoid use with fluvastatin sodium extended-release tablets. ( 7.1 ) • Cyclosporine a…
Fluvastatin Sodium + Niacin— Lipid-modifying doses (≥1 g/day) may enhance risk of myopathy and rhabdomyolysis. Consider concomitant use only if benef…

Moderate (3)

Fluvastatin Sodium + Glibenclamide— Monitor blood glucose levels when fluvastatin is initiated.
Fluvastatin Sodium + Phenytoin— Monitor plasma phenytoin levels when fluvastatin treatment is initiated.
Fluvastatin Sodium + Warfarin— Monitor INR before starting and frequently after fluvastatin initiation or discontinuation to ensure no significant alte…

Fluvastatin Sodium + Cyclosporine⛔Contraindicated

Cyclosporine increases fluvastatin exposure, increasing risk of myopathy and rhabdomyolysis. Avoid concomitant use.

Fluvastatin Sodium + Fluconazole⛔Contraindicated

Fluconazole increases fluvastatin exposure, increasing risk of myopathy and rhabdomyolysis. Avoid concomitant use.

Fluvastatin Sodium + Gemfibrozil⛔Contraindicated

Increased risk of myopathy and rhabdomyolysis when used concomitantly with fluvastatin. Avoid concomitant use.

Fluvastatin Sodium + Colchicine⚠️Major

May increase risk of myopathy and rhabdomyolysis with concomitant use. Consider if benefit outweighs risk and monitor for myopathy symptoms.

Fluvastatin Sodium + Fibrates⚠️Major

Fibrates may cause myopathy when used alone; concomitant use with fluvastatin increases risk of myopathy and rhabdomyolysis. Consider use only if benefit outweighs risk and monitor for symptoms.

Fluvastatin Sodium + Fluvastatin⚠️Major

7 DRUG INTERACTIONS • Gemfibrozil : Avoid use with fluvastatin sodium extended-release tablets. ( 7.1 ) • Cyclosporine and Fluconazole : Avoid use with fluvastatin sodium extended-release tablets. ( 7.1 ) • Fibrates, Lipid-modifying doses (≥ 1 g/day) of Niacin, and Colchicine : Consider if the benefit of concomitant use with fluvastatin sodium extended-release tablets outweighs the increased risk of myopathy and rhabdomyolysis.

Fluvastatin Sodium + Niacin⚠️Major

Lipid-modifying doses (≥1 g/day) may enhance risk of myopathy and rhabdomyolysis. Consider concomitant use only if benefit outweighs risk and monitor for myopathy symptoms.

Fluvastatin Sodium + Glibenclamide🟡Moderate

Monitor blood glucose levels when fluvastatin is initiated.

Fluvastatin Sodium + Phenytoin🟡Moderate

Monitor plasma phenytoin levels when fluvastatin treatment is initiated.

Fluvastatin Sodium + Warfarin🟡Moderate

Monitor INR before starting and frequently after fluvastatin initiation or discontinuation to ensure no significant alteration in INR occurs.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.