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Neomycin

Also known as: Tresaderm, Tri Biozene, Neo-Polycin HC, Neo-Polycin +12 more

11 interactions on record

Neomycin has 11 known drug interactions based on U.S. FDA drug labeling data. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Gentamicin Sulfate, Gorafenib, Methotrexate. Patients taking Neomycin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 11
Major: 7
Moderate: 4

Major (7)

Neomycin + Gentamicin Sulfate— Concurrent and/or sequential use should be avoided due to potential neurotoxicity and nephrotoxicity.
Neomycin + Gorafenib— Neomycin The concomitant use of sorafenib tablets with neomycin decreased the mean AUC of sorafenib, which may decrease …
Neomycin + Methotrexate— If coadministration cannot be avoided, monitor closely for methotrexate adverse reactions when coadministered with: Oral…
Neomycin + Methotrexate Sodium— If coadministration cannot be avoided, monitor closely for methotrexate adverse reactions when coadministered with: Oral…
Neomycin + Neostigmine Methylsulfate— Neomycin has nondepolarizing neuromuscular blocking action; neostigmine dose adjustments may be required to reverse neur…
Neomycin + Pyridostigmine Bromide— Parenteral administration may intensify or produce neuromuscular block and paralysis when used with pyridostigmine.
Neomycin + Vecuronium Bromide— Neomycin may intensify or produce neuromuscular block on its own and can cause unexpected prolongation of vecuronium-ind…

Moderate (4)

Neomycin + Digoxin— Decreases digoxin concentrations. Requires monitoring and dose adjustment.
Neomycin + Lactulose— Elimination of colonic bacteria by neomycin may interfere with lactulose degradation and prevent acidification of coloni…
Neomycin + Lactulose Solution Usp, 10 G/15 Ml— Elimination of colonic bacteria by neomycin may interfere with lactulose degradation and prevent acidification of coloni…
Neomycin + Neomycin Sulfate— Drug Interactions Caution should be taken in concurrent or serial use of other neurotoxic and/or nephrotoxic drugs becau…

Neomycin + Gentamicin Sulfate⚠️Major

Concurrent and/or sequential use should be avoided due to potential neurotoxicity and nephrotoxicity.

Neomycin + Gorafenib⚠️Major

Neomycin The concomitant use of sorafenib tablets with neomycin decreased the mean AUC of sorafenib, which may decrease the antitumor activity. Avoid concomitant use of sorafenib tablets with neomycin.

Neomycin + Methotrexate⚠️Major

If coadministration cannot be avoided, monitor closely for methotrexate adverse reactions when coadministered with: Oral antibiotics (including neomycin) Antifolate drugs (e.g., dapsone, pemetrexed, pyrimethamine and sulfonamides) Oral or intravenous penicillin or sulfonamide antibiotics Aspirin and other nonsteroidal anti- inflammatory drugs Hepatotoxic products Highly protein-bound drugs (e.g., oral anticoagulants, phenytoin, salicylates, sulfonamides, sulfonylureas, and tetracyclines) Proton pump inhibitors Weak acids (e.g., salicylates) Nephrotoxic products Probenecid Nitrous Oxide Coadministration of methotrexate with nitrous oxide anesthesia potentiates the effect of methotrexate on folate-dependent metabolic pathways, which may increase the risk of severe methotrexate adverse reactions.

Neomycin + Methotrexate Sodium⚠️Major

If coadministration cannot be avoided, monitor closely for methotrexate adverse reactions when coadministered with: Oral antibiotics (including neomycin) Antifolate drugs (e.g., dapsone, pemetrexed, pyrimethamine and sulfonamides) Oral or intravenous penicillin or sulfonamide antibiotics Aspirin and other nonsteroidal anti-inflammatory drugs Highly protein-bound drugs (e.g., oral anticoagulants, phenytoin, salicylates, sulfonamides, sulfonylureas, and tetracyclines) Hepatotoxic products Proton pump inhibitors Weak acids (e.g., salicylates) Nephrotoxic products Probenecid Nitrous Oxide Coadministration of methotrexate with nitrous oxide anesthesia potentiates the effect of methotrexate on folate-dependent metabolic pathways, which may increase the risk of severe methotrexate adverse reactions.

Neomycin + Neostigmine Methylsulfate⚠️Major

Neomycin has nondepolarizing neuromuscular blocking action; neostigmine dose adjustments may be required to reverse neuromuscular block.

Neomycin + Pyridostigmine Bromide⚠️Major

Parenteral administration may intensify or produce neuromuscular block and paralysis when used with pyridostigmine.

Neomycin + Vecuronium Bromide⚠️Major

Neomycin may intensify or produce neuromuscular block on its own and can cause unexpected prolongation of vecuronium-induced neuromuscular blockade.

Neomycin + Digoxin🟡Moderate

Decreases digoxin concentrations. Requires monitoring and dose adjustment.

Neomycin + Lactulose🟡Moderate

Elimination of colonic bacteria by neomycin may interfere with lactulose degradation and prevent acidification of colonic contents. Close monitoring recommended during concomitant use.

Neomycin + Lactulose Solution Usp, 10 G/15 Ml🟡Moderate

Elimination of colonic bacteria by neomycin may interfere with lactulose degradation and prevent acidification of colonic contents. Patient status should be closely monitored.

Neomycin + Neomycin Sulfate🟡Moderate

Drug Interactions Caution should be taken in concurrent or serial use of other neurotoxic and/or nephrotoxic drugs because of possible enhancement of the nephrotoxicity and/or ototoxicity of neomycin (see boxed WARNINGS ). Caution should also be taken in concurrent or serial use of other amino-glycosides and polymyxins because they may enhance neomycin’s nephrotoxicity and/or ototoxicity and potentiate neomycin sulfate’s neuromuscular blocking effects. Oral neomycin inhibits the gastrointestinal absorption of penicillin V, oral vitamin B-12, methotrexate and 5-fluorouracil.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.