Desvenlafaxine has 25 known drug interactions based on U.S. FDA drug labeling data. Of these, 6 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Isocarboxazid, Linezolid, Methylene Blue. Patients taking Desvenlafaxine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 25
- Contraindicated
- 6
- Major
- 2
- Moderate
- 15
Contraindicated (6)
- Desvenlafaxine + Isocarboxazid— Concomitant use increases risk of serotonin syndrome. Contraindicated with MAOI or within 14 days of stopping MAOI.
- Desvenlafaxine + Linezolid— Concomitant use increases risk of serotonin syndrome. Contraindicated due to MAOI-like activity.
- Desvenlafaxine + Methylene Blue— Intravenous methylene blue is contraindicated due to risk of serotonin syndrome.
- Desvenlafaxine + Phenelzine— Concomitant use increases risk of serotonin syndrome. Contraindicated with MAOI or within 14 days of stopping MAOI.
- Desvenlafaxine + Selegiline— Concomitant use increases risk of serotonin syndrome. Contraindicated with MAOI or within 14 days of stopping MAOI.
- Desvenlafaxine + Tranylcypromine— Concomitant use increases risk of serotonin syndrome. Contraindicated with MAOI or within 14 days of stopping MAOI.
Major (2)
- Desvenlafaxine + Aspirin— Concurrent use may potentiate risk of upper gastrointestinal bleeding when combined with desvenlafaxine.
- Desvenlafaxine + Warfarin— Altered anticoagulant effects and increased bleeding reported when SNRIs co-administered with warfarin. Careful monitori…
Moderate (15)
- Desvenlafaxine + Amphetamine— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
- Desvenlafaxine + Atomoxetine— Desvenlafaxine increases atomoxetine levels. Reduce dose by up to one-half with 400 mg desvenlafaxine; no adjustment nee…
- Desvenlafaxine + Buspirone— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
- Desvenlafaxine + Desipramine— Desvenlafaxine increases desipramine levels. Reduce dose by up to one-half with 400 mg desvenlafaxine; no adjustment nee…
- Desvenlafaxine + Dextromethorphan— Desvenlafaxine increases dextromethorphan levels. Reduce dose by up to one-half with 400 mg desvenlafaxine; no adjustmen…
- Desvenlafaxine + Ioflupane I-123— Cases of altered DATSCAN uptake that impacted image interpretation have been reported.
- Desvenlafaxine + Lithium— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
- Desvenlafaxine + Metoprolol— Desvenlafaxine increases metoprolol levels. Reduce dose by up to one-half with 400 mg desvenlafaxine; no adjustment need…
- Desvenlafaxine + Nebivolol— Desvenlafaxine increases nebivolol levels. Reduce dose by up to one-half with 400 mg desvenlafaxine; no adjustment neede…
- Desvenlafaxine + Perphenazine— Desvenlafaxine increases perphenazine levels. Reduce dose by up to one-half with 400 mg desvenlafaxine; no adjustment ne…
- Desvenlafaxine + St. John'S Wort— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
- Desvenlafaxine + Tolterodine— Desvenlafaxine increases tolterodine levels. Reduce dose by up to one-half with 400 mg desvenlafaxine; no adjustment nee…
- Desvenlafaxine + Tramadol— Concomitant use increases risk of serotonin syndrome. Monitor for serotonin syndrome symptoms; consider discontinuation …
- Desvenlafaxine + Triptans— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
- Desvenlafaxine + Tryptophan— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…