Nicotine has 17 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Dihydroergotamine Mesylate, Acetaminophen, Caffeine. Patients taking Nicotine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 17
- Major
- 1
- Moderate
- 16
Major (1)
- Nicotine + Dihydroergotamine Mesylate— Nicotine may provoke vasoconstriction, predisposing to greater ischemic response to ergot therapy.
Moderate (16)
- Nicotine + Acetaminophen— Smoking cessation with nicotine replacement may require dose decrease due to deinduction of hepatic enzymes.
- Nicotine + Caffeine— Smoking cessation with nicotine replacement may require dose decrease due to deinduction of hepatic enzymes.
- Nicotine + Ergotamine Tartrate— May provoke vasoconstriction in some patients, predisposing to greater ischemic response to ergot therapy.
- Nicotine + Ergotamine Tartrate And Caffeine— May provoke vasoconstriction in some patients, predisposing to greater ischemic response to ergot therapy.
- Nicotine + Heparin Sodium— May partially counteract the anticoagulant action of heparin. Careful monitoring recommended.
- Nicotine + Imipramine— Smoking cessation with nicotine replacement may require dose decrease due to deinduction of hepatic enzymes.
- Nicotine + Insulin Human— Smoking cessation with nicotine replacement may require dose decrease due to increased subcutaneous insulin absorption.
- Nicotine + Isoproterenol— Smoking cessation with nicotine replacement may require dose increase due to decreased circulating catecholamines.
- Nicotine + Labetalol— Smoking cessation with nicotine replacement may require dose decrease due to decreased circulating catecholamines.
- Nicotine + Oxazepam— Smoking cessation with nicotine replacement may require dose decrease due to deinduction of hepatic enzymes.
- Nicotine + Pentazocine— Smoking cessation with nicotine replacement may require dose decrease due to deinduction of hepatic enzymes.
- Nicotine + Phenylephrine Hci— Smoking cessation with nicotine replacement may require dose increase due to decreased circulating catecholamines.
- Nicotine + Prazosin— Smoking cessation with nicotine replacement may require dose decrease due to decreased circulating catecholamines.
- Nicotine + Propranolol— Smoking cessation with nicotine replacement may require dose decrease due to deinduction of hepatic enzymes.
- Nicotine + Theophylline— Smoking cessation with nicotine replacement may require dose decrease due to deinduction of hepatic enzymes.
- Nicotine + Xylometazoline— Nasal vasoconstrictor further prolongs time to peak nicotine concentration in patients with rhinitis.