Nitric Oxide has 37 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 30 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Vardenafil, Vardenafil Hydrochloride, Articaine Hydrochloride And Epinephrine. Patients taking Nitric Oxide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 37
- Contraindicated
- 2
- Major
- 30
- Moderate
- 5
Contraindicated (2)
- Nitric Oxide + Vardenafil— Concomitant use of vardenafil and nitric oxide donors is contraindicated.
- Nitric Oxide + Vardenafil Hydrochloride— Concomitant use of vardenafil hydrochloride and nitric oxide donors is contraindicated.
Major (30)
- Nitric Oxide + Articaine Hydrochloride And Epinephrine— Increased risk of methemoglobinemia when concurrently exposed to articaine.
- Nitric Oxide + Articaine Hydrochloride And Epinephrine Bitartrate— Increased risk of developing methemoglobinemia when concurrently exposed to this nitrate.
- Nitric Oxide + Benzocaine, Butamben, And Tetracaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed to this nitrate/nitrite oxidizing agent with local anesthe…
- Nitric Oxide + Bupivacaine And Meloxicam— Increased risk of methemoglobinemia when local anesthetics are used concomitantly with nitrates/nitrites.
- Nitric Oxide + Bupivacaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Nitric Oxide + Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine— Increased risk of methemoglobinemia when used with ropivacaine.
- Nitric Oxide + Lidocaine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Nitric Oxide + Lidocaine 5%— May cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
- Nitric Oxide + Lidocaine And Capsaicin— May increase risk of methemoglobinemia when used concurrently with local anesthetics.
- Nitric Oxide + Lidocaine And Prilocaine— Nitrate/nitrite; increased risk of methemoglobinemia when concurrently exposed.
- Nitric Oxide + Lidocaine Hydrochloride— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
- Nitric Oxide + Lidocaine Hydrochloride And Epinephrine Bitartrate— Associated with methemoglobinemia risk when concurrent exposure occurs with local anesthetics.
- Nitric Oxide + Lidocaine Hydrochloride And Hydrocortisone Acetate— Increased risk of methemoglobinemia when local anesthetic is concurrently exposed to nitrates/nitrites.
- Nitric Oxide + Lidocaine Hydrochloride Monohydrate— Concurrent exposure increases risk of methemoglobinemia in patients administered local anesthetics.
- Nitric Oxide + Lidocaine Patch 5%— Increased risk of methemoglobinemia when concurrently exposed; nitrates/nitrites may cause methemoglobinemia when used w…
- Nitric Oxide + Lidocaine, Isopropyl Alcohol— Increased risk of methemoglobinemia when used with lidocaine.
- Nitric Oxide + Lidocaine, Menthol— Increased risk of methemoglobinemia when lidocaine is concurrently exposed to oxidizing agents.
- Nitric Oxide + Lidothol Patch— Increased risk of methemoglobinemia when local anesthetics are concurrently exposed to nitric oxide.
- Nitric Oxide + Marcaine, Lidocaine, Kenalog, Povidone Iodine— Increased risk of methemoglobinemia when concurrently exposed to nitrates/nitrites.
- Nitric Oxide + Mepivacaine Hydrochloride— Concurrent exposure increases risk of methemoglobinemia in patients administered mepivacaine.
- Nitric Oxide + Nitroglycerin— May increase the risk of developing methemoglobinemia when used with nitric oxide.
- Nitric Oxide + Penicillin G Benzathine And Penicillin G Procaine— Increased risk of methemoglobinemia when penicillin is concurrently administered with nitric oxide.
- Nitric Oxide + Prilocaine— May increase the risk of developing methemoglobinemia when used with nitric oxide.
- Nitric Oxide + Prilocaine Hcl And Epinephrine— Increased risk of methemoglobinemia when prilocaine is concurrently exposed to nitric oxide.
- Nitric Oxide + Prilocaine Hydrochloride— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Nitric Oxide + Ropivacaine Hydrochloride— Increased risk of developing methemoglobinemia when concurrently exposed to nitric oxide.
- Nitric Oxide + Sodium Nitroprusside— May increase the risk of developing methemoglobinemia when used with nitric oxide.
- Nitric Oxide + Triamcinolone Acetonide— Increased risk of methemoglobinemia when concurrently exposed.
- Nitric Oxide + Triethanolamine Salicylate— Increased risk of methemoglobinemia when used concurrently with triethanolamine salicylate.
- Nitric Oxide + Trubrexa Patch Er— Nitrate; increased risk of methemoglobinemia when concurrently exposed with Trubrexa Transdermal Patch.
Moderate (5)
- Nitric Oxide + Bupivacaine— May increase risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Nitric Oxide + Bupivacaine Hydrochloride And Epinephrine Bitartrate— Increased risk of methemoglobinemia when concurrently exposed.
- Nitric Oxide + Bupivacaine Hydrochloride With Dextrose— Increased risk of developing methemoglobinemia when concurrently exposed.
- Nitric Oxide + Lidocaine And Tetracaine— Nitrate/nitrite that increases risk of methemoglobinemia when used concomitantly with lidocaine and tetracaine.
- Nitric Oxide + Marcaine, Kenalog, Povidone Iodine— Increased risk of methemoglobinemia when concurrently exposed to nitrates/nitrites with bupivacaine.