Pramipexole has 4 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Metoclopramide, Metoclopramide Hydrochloride, Butyrophenones. Patients taking Pramipexole should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 4
- Contraindicated
- 2
- Moderate
- 2
Contraindicated (2)
- Pramipexole + Metoclopramide— Dopaminergic agonist with opposing effects on dopamine. Avoid concomitant use to prevent exacerbation of parkinsonian sy…
- Pramipexole + Metoclopramide Hydrochloride— Dopaminergic agonist with opposing effects on dopamine; potential exacerbation of symptoms. Avoid concomitant use.
Moderate (2)
- Pramipexole + Butyrophenones— Dopamine antagonists may diminish the effectiveness of pramipexole.
- Pramipexole + Phenothiazines— Dopamine antagonists may diminish the effectiveness of pramipexole.