Nitrous Oxide has 41 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 28 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Methotrexate, Methotrexate Sodium, Articaine Hydrochloride And Epinephrine. Patients taking Nitrous Oxide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 41
- Contraindicated
- 2
- Major
- 28
- Moderate
- 11
Contraindicated (2)
- Nitrous Oxide + Methotrexate— Anesthetic that potentiates methotrexate effects on folate-dependent metabolic pathways, increasing risk of severe adver…
- Nitrous Oxide + Methotrexate Sodium— Nitrous oxide anesthesia potentiates methotrexate effects on folate-dependent metabolic pathways, increasing risk of sev…
Major (28)
- Nitrous Oxide + Articaine Hydrochloride And Epinephrine— Increased risk of methemoglobinemia when concurrently exposed to articaine.
- Nitrous Oxide + Articaine Hydrochloride And Epinephrine Bitartrate— Increased risk of developing methemoglobinemia when concurrently exposed to this nitrous oxide.
- Nitrous Oxide + Benzocaine, Butamben, And Tetracaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed to this nitrate/nitrite oxidizing agent with local anesthe…
- Nitrous Oxide + Bupivacaine And Meloxicam— Increased risk of methemoglobinemia when local anesthetics are used concomitantly with nitrates/nitrites.
- Nitrous Oxide + Bupivacaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Nitrous Oxide + Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine— Increased risk of methemoglobinemia when used with ropivacaine.
- Nitrous Oxide + Lidocaine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Nitrous Oxide + Lidocaine 5%— Nitrite that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
- Nitrous Oxide + Lidocaine And Capsaicin— Nitrite drug that increases risk of methemoglobinemia when used concurrently with lidocaine and capsaicin patch.
- Nitrous Oxide + Lidocaine And Prilocaine— Nitrate/nitrite; increased risk of methemoglobinemia when concurrently exposed.
- Nitrous Oxide + Lidocaine Hydrochloride— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
- Nitrous Oxide + Lidocaine Hydrochloride And Epinephrine Bitartrate— Associated with methemoglobinemia risk when concurrent exposure occurs with local anesthetics.
- Nitrous Oxide + Lidocaine Hydrochloride And Hydrocortisone Acetate— Increased risk of methemoglobinemia when local anesthetic is concurrently exposed to nitrates/nitrites.
- Nitrous Oxide + Lidocaine Hydrochloride Monohydrate— Concurrent exposure increases risk of methemoglobinemia in patients administered local anesthetics.
- Nitrous Oxide + Lidocaine Patch 5%— Increased risk of methemoglobinemia when concurrently exposed; nitrates/nitrites may cause methemoglobinemia when used w…
- Nitrous Oxide + Lidocaine, Isopropyl Alcohol— Increased risk of methemoglobinemia when used with lidocaine.
- Nitrous Oxide + Lidocaine, Menthol— Increased risk of methemoglobinemia when lidocaine is concurrently exposed to oxidizing agents.
- Nitrous Oxide + Lidothol Patch— Increased risk of methemoglobinemia when local anesthetics are concurrently exposed to nitrous oxide.
- Nitrous Oxide + Marcaine, Lidocaine, Kenalog, Povidone Iodine— Increased risk of methemoglobinemia when concurrently exposed to nitrates/nitrites.
- Nitrous Oxide + Mepivacaine Hydrochloride— Concurrent exposure increases risk of methemoglobinemia in patients administered mepivacaine.
- Nitrous Oxide + Midazolam Hydrochloride— CNS depressant that accentuates the sedative effect of midazolam, requiring dose adjustment.
- Nitrous Oxide + Penicillin G Benzathine And Penicillin G Procaine— Increased risk of methemoglobinemia when penicillin is concurrently administered with nitrous oxide.
- Nitrous Oxide + Prilocaine Hcl And Epinephrine— Increased risk of methemoglobinemia when prilocaine is concurrently exposed to nitrous oxide.
- Nitrous Oxide + Prilocaine Hydrochloride— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Nitrous Oxide + Ropivacaine Hydrochloride— Increased risk of developing methemoglobinemia when concurrently exposed to nitrous oxide.
- Nitrous Oxide + Triamcinolone Acetonide— Increased risk of methemoglobinemia when concurrently exposed.
- Nitrous Oxide + Triethanolamine Salicylate— Increased risk of methemoglobinemia when used concurrently with triethanolamine salicylate.
- Nitrous Oxide + Trubrexa Patch Er— Increased risk of methemoglobinemia when used with Trubrexa Transdermal Patch.
Moderate (11)
- Nitrous Oxide + Bupivacaine— May increase risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Nitrous Oxide + Bupivacaine Hydrochloride And Epinephrine Bitartrate— Increased risk of methemoglobinemia when concurrently exposed.
- Nitrous Oxide + Bupivacaine Hydrochloride With Dextrose— Increased risk of developing methemoglobinemia when concurrently exposed.
- Nitrous Oxide + Desflurane— Concomitant use of N2O reduces the MAC of desflurane. Adjust dose accordingly.
- Nitrous Oxide + Folic Acid— Nitrous oxide indirectly decreases folate activity by inactivating vitamin B12 and downstream methylation pathways.
- Nitrous Oxide + Isoflurane— Nitrous oxide decreases the minimum alveolar concentration (MAC) of isoflurane. Dose adjustment required.
- Nitrous Oxide + Lidocaine And Tetracaine— Nitrate/nitrite that increases risk of methemoglobinemia when used concomitantly with lidocaine and tetracaine.
- Nitrous Oxide + Marcaine, Kenalog, Povidone Iodine— Increased risk of methemoglobinemia when concurrently exposed to nitrates/nitrites with bupivacaine.
- Nitrous Oxide + Propofol— May increase anesthetic/sedative and cardiorespiratory effects; propofol dose may require adjustment during maintenance.
- Nitrous Oxide + Propofol Injectable Emulsion— May increase anesthetic/sedative and cardiorespiratory effects; propofol administration rate should be adjusted during m…
- Nitrous Oxide + Sevoflurane— Anesthetic requirement for sevoflurane is decreased when administered in combination with nitrous oxide; MAC equivalent …